Research ArticleRadiopharmacy & Adjunctive Medications

Can 68Ga-DOTA Peptides Be Potential Radiotracers for PET Imaging of the Spleen?

Ismet Sarikaya, Abdelhamid H. Elgazzar, Ali Sarikaya, Naheel Alnafisi and Saud Alenezi
Journal of Nuclear Medicine Technology June 2018, 46 (2) 133-135; DOI: https://doi.org/10.2967/jnmt.117.203448

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    68Ga-DOTANOC whole-body PET maximum-intensity projection demonstrates normal distribution of activity in spleen, liver, pituitary gland, adrenal glands, pancreatic head, and bowel, with excreted activity in kidneys and bladder.

  • FIGURE 2.
    FIGURE 2.

    Basic anatomy of spleen: red pulp (RP), white pulp (WP), vein (V), artery (A), and splenic capsule (C).

  • FIGURE 3.
    FIGURE 3.

    Selected transaxial CT (top), 68Ga-DOTANOC PET (middle), and 68Ga-DOTANOC PET/CT (bottom) images of 3 patients. PET demonstrates physiologic high uptake in spleen, with slight heterogeneous distribution of activity. Slightly more prominent uptake in periphery of spleen and focally throughout splenic parenchyma is likely due to subcapsular and parenchymal red pulp. Central and hilar areas showing less uptake are likely due to splenic vascular structures or white pulp.

  • FIGURE 4.
    FIGURE 4.

    111In-pentetreotide posterior whole-body and selected transaxial CT, SPECT, and SPECT/CT images. Physiologic uptake in spleen is high and image resolution poor, compared with higher-resolution 68Ga-DOTANOC images.

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