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Comparison of Methods of Attenuation and Scatter Correction in Brain Perfusion SPECT

Masuo Hayashi, Jun Deguchi, Keita Utsunomiya, Makoto Yamada, Tsuyoshi Komori, Masayasu Takeuchi, Kensei Kanna and Isamu Narabayashi
Journal of Nuclear Medicine Technology December 2005, 33 (4) 224-229;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    ROIs for human study are set in right and left perforator regions and in right and left cortical branch regions at level of basal ganglia (4 ROIs in total) and in right and left cortical branch regions at level of body of lateral ventricle (2 ROIs in total).

  • FIGURE 2.
    FIGURE 2.

    Profile curves obtained from humans at level of basal ganglia (A) and level of body of lateral ventricle (B). Profile curves obtained by TEW + Chang and TEW + CT methods were similar for regions with low regional CBF values, such as white matter and ventricles. However, profile curves obtained by TEW + CT method were higher in regions with high regional CBF values, such as gray matter and thalamus. In Chang method, difference between higher parts and lower parts of profile curves was less than in the other 2 methods, and regional CBF values were high, especially in white matter and ventricle. ARG = autoradiography.

  • FIGURE 3.
    FIGURE 3.

    XeCT/CBF image and autoradiography/CBF images of the 3 methods used on 67-y-old woman with right posterior cerebral artery occlusion. ARG = autoradiography.

  • FIGURE 4.
    FIGURE 4.

    Correlations between regional CBF values obtained by each autoradiography/CBF method and regional CBF values obtained by XeCT/CBF method in clinical cases. In each area, x-coefficient of regional CBF values obtained by TEW + CT method to those obtained by XeCT/CBF method improved maximally. Correlation was better in methods using scatter and attenuation correction than in method using attenuation correction alone. ARG = autoradiography.

  • FIGURE 5.
    FIGURE 5.

    Correlations between regional CBF values obtained by each autoradiography/CBF method and regional CBF values obtained by XeCT/CBF method for each ROI: (A) cortical branch region at level of basal ganglia; (B) perforator region at level of basal ganglia; (C) cortical branch region at level of body of lateral ventricle. In each region, x-coefficient of regional CBF values obtained by TEW + CT method to those obtained by XeCT/CBF method improved maximally. In all methods, correlations were better in cortical branch region than in perforator region. ARG = autoradiography.

Tables

  • TABLE 1

    Methods

    MethodPrefilterReconstruction filterScatter correctionAttenuation correction
    ChangButterworthRampNoneChang (0.070 cm−1)
    TEW + ChangButterworthRampTEWChang (0.146 cm−1)
    TEW + CTButterworthRampTEWCT map
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