RT Journal Article
SR Electronic
T1 Comparison of Methods of Attenuation and Scatter Correction in Brain Perfusion SPECT
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 224
OP 229
VO 33
IS 4
A1 Hayashi, Masuo
A1 Deguchi, Jun
A1 Utsunomiya, Keita
A1 Yamada, Makoto
A1 Komori, Tsuyoshi
A1 Takeuchi, Masayasu
A1 Kanna, Kensei
A1 Narabayashi, Isamu
YR 2005
UL http://tech.snmjournals.org/content/33/4/224.abstract
AB Objective: The radioactivity count distribution in the brain must be determined accurately to accurately measure cerebral blood flow (CBF). Scatter and attenuation are factors that compromise the accuracy of determining radioactivity counts in the brain. Methods: We compared regional CBF in patients by an autoradiographic method using N-isopropyl-p-[123I] iodoamphetamine when, first, attenuation correction alone was performed uniformly on SPECT images by using empiric μ-values (Chang method); second, scatter correction was performed and the μ-values of a homogeneous-attenuation body of water were used for attenuation correction (triple-energy window [TEW] + Chang method); and third, scatter correction was performed and the μ-values calculated by CT were used for attenuation correction (TEW + CT method). We also compared regional CBF measured by these methods with the values obtained by the xenon CT/CBF method, which uses CT and stable xenon. Results: Scatter correction reduced overestimation of regional CBF in low-flow regions. The TEW + CT method yielded better regional and overall correlations with the xenon CT/CBF method than did either of the other methods. Conclusion: The TEW + CT method of correction gave the most accurate measurements of regional CBF.