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Research ArticleRadiopharmacy & Adjunctive Medications

Direct Synthesis of Radioactive Gold Nanoparticles Using a Research Nuclear Reactor

Maria C. Garcia Toro, Joshua P. Schlegel and Carlos H. Castano Giraldo
Journal of Nuclear Medicine Technology September 2018, 46 (3) 280-284; DOI: https://doi.org/10.2967/jnmt.117.206367
Maria C. Garcia Toro
Department of Mining and Nuclear Engineering, Missouri University of Science and Technology, Rolla, Missouri
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Joshua P. Schlegel
Department of Mining and Nuclear Engineering, Missouri University of Science and Technology, Rolla, Missouri
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Carlos H. Castano Giraldo
Department of Mining and Nuclear Engineering, Missouri University of Science and Technology, Rolla, Missouri
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  • FIGURE 1.
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    FIGURE 1.

    Transmission electron micrographs of radioactive gold nanoparticles that were irradiated at 200 kW for 0.5 min for sample 1 (A), 1 min for sample 2 (B), 3 min for sample 3 (C), 5 min for sample 4 (D), 10 min for sample 5 (E), 30 min for sample 6 (E), and 60 min for sample 7 (G).

  • FIGURE 2.
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    FIGURE 2.

    Variation of average size and SD with irradiation time.

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    FIGURE 3.

    Particle population vs. probability for sample 5.

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    FIGURE 4.

    Energy-dispersive spectroscopy graph for sample 5.

Tables

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    TABLE 1

    Average Particle Size with Irradiation Time

    SampleIrradiation time (min)Average size (nm)SD (nm)SD (%)
    10.527120776
    2122112657
    331247560
    45864755
    510563461
    630371643
    76019842
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    TABLE 2

    Weight and Atomic Composition of Elements in the Spectrum

    ElementWeight (%)Atomic (%)Uncertainty (%)
    Chlorine28693
    Gold723110
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    TABLE 3

    Calculated Activities for Each Irradiated Sample

    Time (min)Activity (MBq/mL)Error (%)
    0.50.345.2
    10.695.0
    32.065.0
    53.435.0
    106.855.0
    3020.525.0
    6040.945.0
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Journal of Nuclear Medicine Technology: 46 (3)
Journal of Nuclear Medicine Technology
Vol. 46, Issue 3
September 1, 2018
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Direct Synthesis of Radioactive Gold Nanoparticles Using a Research Nuclear Reactor
Maria C. Garcia Toro, Joshua P. Schlegel, Carlos H. Castano Giraldo
Journal of Nuclear Medicine Technology Sep 2018, 46 (3) 280-284; DOI: 10.2967/jnmt.117.206367

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Direct Synthesis of Radioactive Gold Nanoparticles Using a Research Nuclear Reactor
Maria C. Garcia Toro, Joshua P. Schlegel, Carlos H. Castano Giraldo
Journal of Nuclear Medicine Technology Sep 2018, 46 (3) 280-284; DOI: 10.2967/jnmt.117.206367
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Keywords

  • gold nanoparticles
  • radioactive nanoparticles
  • cancer nanotechnology
  • nanomaterials
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