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Research ArticleRadiopharmacy & Adjunctive Medications

A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FB-A20FMDV2 for Imaging the Integrin αvβ6

Nicholas Keat, Julia Kenny, Keguan Chen, Mayca Onega, Nadia Garman, Robert J. Slack, Christine A. Parker, R. Thomas Lumbers, Will Hallett, Azeem Saleem, Jan Passchier and Pauline T. Lukey
Journal of Nuclear Medicine Technology June 2018, 46 (2) 136-143; DOI: https://doi.org/10.2967/jnmt.117.203547
Nicholas Keat
1Imanova Ltd., London, United Kingdom
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Julia Kenny
2In Vitro In Vivo Translation, GlaxoSmithKline R&D, Ware, United Kingdom
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Keguan Chen
3Immunogenicity and Clinical Immunology, GlaxoSmithKline R&D, Upper Merion, Pennsylvania
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Mayca Onega
1Imanova Ltd., London, United Kingdom
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Nadia Garman
4Clinical Operations, GlaxoSmithKline R&D, Stevenage, United Kingdom
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Robert J. Slack
5Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, Stevenage, United Kingdom; and
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Christine A. Parker
6Clinical Imaging, GlaxoSmithKline R&D, Stevenage, United Kingdom
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R. Thomas Lumbers
5Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, Stevenage, United Kingdom; and
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Will Hallett
1Imanova Ltd., London, United Kingdom
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Azeem Saleem
1Imanova Ltd., London, United Kingdom
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Jan Passchier
1Imanova Ltd., London, United Kingdom
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Pauline T. Lukey
5Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, Stevenage, United Kingdom; and
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Article Information

vol. 46 no. 2 136-143
DOI 
https://doi.org/10.2967/jnmt.117.203547
PubMed 
29438002

Published By 
Society of Nuclear Medicine
Print ISSN 
0091-4916
Online ISSN 
1535-5675
History 
  • Received for publication October 10, 2017
  • Accepted for publication December 6, 2017
  • Published online June 5, 2018.

Article Versions

  • previous version (February 2, 2018 - 12:53).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2018 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Nicholas Keat1,
  2. Julia Kenny2,
  3. Keguan Chen3,
  4. Mayca Onega1,
  5. Nadia Garman4,
  6. Robert J. Slack5,
  7. Christine A. Parker6,
  8. R. Thomas Lumbers5,
  9. Will Hallett1,
  10. Azeem Saleem1,
  11. Jan Passchier1 and
  12. Pauline T. Lukey5
  1. 1Imanova Ltd., London, United Kingdom
  2. 2In Vitro In Vivo Translation, GlaxoSmithKline R&D, Ware, United Kingdom
  3. 3Immunogenicity and Clinical Immunology, GlaxoSmithKline R&D, Upper Merion, Pennsylvania
  4. 4Clinical Operations, GlaxoSmithKline R&D, Stevenage, United Kingdom
  5. 5Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, Stevenage, United Kingdom; and
  6. 6Clinical Imaging, GlaxoSmithKline R&D, Stevenage, United Kingdom
  1. For correspondence or reprints contact: Pauline T. Lukey, Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, Gunnels Wood Rd., Stevenage SG1 2NY, U.K. E-mail: pauline.t.lukey{at}gsk.com
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  • Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)
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  • A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor
    Toby M. Maher, Juliet K. Simpson, Joanna C. Porter, Frederick J. Wilson, Robert Chan, Rhena Eames, Yi Cui, Sarah Siederer, Simon Parry, Julia Kenny, Robert J. Slack, Jagdeep Sahota, Lyn Paul, Peter Saunders, Philip L. Molyneaux, Pauline T. Lukey, Gaia Rizzo, Graham E. Searle, Richard P. Marshall, Azeem Saleem, Arthur R. Kang’ombe, David Fairman, William A. Fahy, Mitra Vahdati-Bolouri
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  • Clinical Translation of a68Ga-Labeled Integrin αvβ6–Targeting Cyclic Radiotracer for PET Imaging of Pancreatic Cancer
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    Frontiers in Medicine 2022 9
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    2021 1295
  • Delivery of Theranostic Nanoparticles to Various Cancers by Means of Integrin-Binding Peptides
    Elena A. Egorova, Maxim P. Nikitin
    International Journal of Molecular Sciences 2022 23 22

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Journal of Nuclear Medicine Technology: 46 (2)
Journal of Nuclear Medicine Technology
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June 1, 2018
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A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FB-A20FMDV2 for Imaging the Integrin αvβ6
Nicholas Keat, Julia Kenny, Keguan Chen, Mayca Onega, Nadia Garman, Robert J. Slack, Christine A. Parker, R. Thomas Lumbers, Will Hallett, Azeem Saleem, Jan Passchier, Pauline T. Lukey
Journal of Nuclear Medicine Technology Jun 2018, 46 (2) 136-143; DOI: 10.2967/jnmt.117.203547

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A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FB-A20FMDV2 for Imaging the Integrin αvβ6
Nicholas Keat, Julia Kenny, Keguan Chen, Mayca Onega, Nadia Garman, Robert J. Slack, Christine A. Parker, R. Thomas Lumbers, Will Hallett, Azeem Saleem, Jan Passchier, Pauline T. Lukey
Journal of Nuclear Medicine Technology Jun 2018, 46 (2) 136-143; DOI: 10.2967/jnmt.117.203547
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Cited By...

  • Clinical Translation of a 68Ga-Labeled Integrin {alpha}v{beta}6-Targeting Cyclic Radiotracer for PET Imaging of Pancreatic Cancer
  • Preclinical Development and First-in-Human Imaging of the Integrin {alpha}v{beta}6 with [18F]{alpha}v{beta}6-Binding Peptide in Metastatic Carcinoma
  • Google Scholar

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Keywords

  • FTIH
  • PET
  • αvβ6
  • integrin
  • A20FMDV2
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