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Research ArticleIMAGING

Characterization of Geometric Uncertainties of a Dose Calibrator During Measurement of 90Y Activity

João A.M. Santos, Anabela G. Dias and Artur L. Bastos
Journal of Nuclear Medicine Technology June 2011, 39 (2) 125-130; DOI: https://doi.org/10.2967/jnmt.110.077404
João A.M. Santos
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Anabela G. Dias
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Artur L. Bastos
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  • FIGURE 1.
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    FIGURE 1.

    Schematic of CRC-15R dose calibrator used in this study. A and B represent ionization chamber and inner metallic wall housings; C represents removable plastic protection for contamination prevention; D and E represent 2 key features of plastic source holder: vial holder and syringe holder, respectively.

  • FIGURE 2.
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    FIGURE 2.

    Responsiveness curves, r(x), of dose calibrator as function of axial longitudinal distance, x. Responsiveness was defined as Aapp normalized by its maximum value. Three different responses of dose calibrator for 90Y with and without plastic insert and 99mTc with plastic insert are shown. Points i and ii refer to regions shown in Figure 1.

  • FIGURE 3.
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    FIGURE 3.

    Aapp as function of axial longitudinal distance obtained with 90Y point source with and without plastic sample holder. Both cases were obtained using plastic insert. Note difference between the 2 curves. Regions (points) i, ii, iii, and iv (Fig. 1) are also indicated. Inset graphic shows percentage variation relative to maximum value (near x = 14 cm) at initial part of curve obtained with plastic holder.

  • FIGURE 4.
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    FIGURE 4.

    Percentage variation of Aapp measured with same activity for both radionuclides (90Y and 99mTc) and with volume varied using 10-mL syringe.

  • FIGURE 5.
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    FIGURE 5.

    Mean values of Aapp as function of source holder angle. Source holder was varied over 360° by 10° steps. A 10-mL syringe was used in measurements.

  • FIGURE 6.
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    FIGURE 6.

    Aapp percentage error associated with plastic vial holder (above region iii in Fig. 3) obtained by solving Equation 5. Both logarithmic and linear scale representations are shown.

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Journal of Nuclear Medicine Technology: 39 (2)
Journal of Nuclear Medicine Technology
Vol. 39, Issue 2
June 1, 2011
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Characterization of Geometric Uncertainties of a Dose Calibrator During Measurement of 90Y Activity
João A.M. Santos, Anabela G. Dias, Artur L. Bastos
Journal of Nuclear Medicine Technology Jun 2011, 39 (2) 125-130; DOI: 10.2967/jnmt.110.077404

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Characterization of Geometric Uncertainties of a Dose Calibrator During Measurement of 90Y Activity
João A.M. Santos, Anabela G. Dias, Artur L. Bastos
Journal of Nuclear Medicine Technology Jun 2011, 39 (2) 125-130; DOI: 10.2967/jnmt.110.077404
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