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Research ArticleRadiopharmacy & Adjunctive Medications

Investigation of the Importance of Applying Various Methods of Calculation in Determining the Blood-Absorbed Dose for Patients with Differentiated Thyroid Carcinoma

Issa A. Al-Shakhrah
Journal of Nuclear Medicine Technology December 2023, 51 (4) 296-301; DOI: https://doi.org/10.2967/jnmt.122.265214
Issa A. Al-Shakhrah
Physics Department, University of Jordan, Amman, Jordan
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Figures

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  • FIGURE 1.
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    FIGURE 1.

    Scatterplots of blood-absorbed doses by first and second methods.

  • FIGURE 2.
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    FIGURE 2.

    Scatterplots of blood-absorbed doses by first and fourth methods.

  • FIGURE 3.
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    FIGURE 3.

    Scatterplots of difference in blood-absorbed doses by plotting first and second methods, as y-axis, against mean absorbed doses by first and second methods, as x-axis (Bland–Altman analysis). Solid line indicates mean difference between first method and second methods, and dotted lines indicate 95% limits of agreement (mean ± 1.96 SD).

  • FIGURE 4.
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    FIGURE 4.

    Scatterplots of difference in blood-absorbed doses by plotting first and fourth methods, as y-axis, against mean absorbed doses by first and fourth methods, as x-axis (Bland–Altman analysis). Solid line indicates mean difference between first method and fourth methods, and dotted lines indicate 95% limits of agreement (mean ± 1.96 SD).

Tables

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    TABLE 1.

    Comparison of Mean Total Absorbed Dose with 3.7 GBq of Administered Activity in Prior and Present Investigations

    InvestigationMean total blood- absorbed dose (Gy)
    Prior
     M’Kacher et al. (27)0.54
     Monsieurs et al. (26)0.32
     Hänscheid et al. (28)0.45
     Piruzan et al. (12)0.62
     Benua et al. (4)0.65 ± 0.19
     Sawka et al. (29)0.56 ± 0.15
    Present
     First method0.46 ± 0.12
     Second method0.45 ± 0.13
     Third method0.46 ± 0.19
     Fourth method0.62 ± 0.23
    • View popup
    TABLE 2.

    Estimated Total Blood-Absorbed Doses by First Method (13), Second Method (14), Third Method (3,16), and Fourth Method (12)

    ParameterAbsorbed dose (Gy)
    First methodSecond methodThird methodFourth method
    Patient no.
     10.230.280.230.33
     20.260.290.270.37
     30.280.310.290.38
     40.300.300.310.40
     50.330.390.380.46
     60.340.390.290.47
     70.370.430.520.52
     80.380.410.430.53
     90.350.550.360.55
     100.400.450.410.57
     110.420.490.450.58
     120.440.380.370.61
     130.430.480.470.64
     140.480.380.360.65
     150.530.430.450.68
     160.470.660.580.69
     170.510.400.400.70
     180.660.430.440.83
     190.570.580.640.81
     200.700.630.730.93
     210.740.670.891.00
     221.040.811.041.33
     230.260.270.340.37
     240.340.310.310.47
     250.340.340.380.49
     260.440.450.380.62
     270.670.520.630.89
    Female and male
     Average0.460.450.460.62
     SD0.180.130.1890.23
     Median0.420.430.420.58
     Maximum1.040.811.041.33
     Minimum0.230.270.260.33
    Female
     Average0.470.460.470.64
     SD0.190.140.200.23
     Median0.430.430.420.59
     Maximum1.040.811.041.33
     Minimum0.230.280.260.33
    Male
     Average0.410.380.410.57
     SD0.150.100.130.20
     Median0.340.380.380.49
     Maximum0.670.520.630.89
     Minimum0.260.270.310.37
    • View popup
    TABLE 3.

    Blood-Absorbed Doses and Associated Parameters Used to Plot Figures 1 and 2

    Patient no.ABC = (A + B)/2D = (A − B)E = (A − B)/2FG
    10.22570.28490.2553−0.05920.00860.211−0.193
    20.2590.28860.2738−0.02960.00860.211−0.193
    30.28120.31080.296−0.02960.00860.211−0.193
    40.30340.2960.29970.00740.00860.211−0.193
    50.32930.38850.3589−0.05920.00860.211−0.193
    60.33670.39220.36445−0.05550.00860.211−0.193
    70.370.42550.39775−0.05550.00860.211−0.193
    80.38480.41440.3996−0.02960.00860.211−0.193
    90.35150.54760.44955−0.19610.00860.211−0.193
    100.39590.44770.4218−0.05180.00860.211−0.193
    110.41810.48840.45325−0.07030.00860.211−0.193
    120.4440.38480.41440.05920.00860.211−0.193
    130.43290.47730.4551−0.04440.00860.211−0.193
    140.48470.37740.431050.10730.00860.211−0.193
    150.53280.42920.4810.10360.00860.211−0.193
    160.46990.66230.5661−0.19240.00860.211−0.193
    170.51060.40330.456950.10730.00860.211−0.193
    180.65860.42550.542050.23310.00860.211−0.193
    190.56980.58460.5772−0.01480.00860.211−0.193
    200.7030.62530.664150.07770.00860.211−0.193
    210.740.6660.7030.0740.00860.211−0.193
    221.0360.8140.9250.2220.00860.211−0.193
    230.26270.26640.26455−0.00370.00860.211−0.193
    240.34410.31450.32930.02960.00860.211−0.193
    250.33670.37740.35705−0.04070.00860.211−0.193
    260.4440.44770.44585−0.00370.00860.211−0.193
    270.6660.5180.5920.1480.00860.211−0.193
    • A = absorbed radiation dose by first method; B = absorbed radiation dose by second method; C = mean blood-absorbed doses by first and second methods; D = difference between blood-absorbed doses by first and second methods; E = mean difference between blood-absorbed doses; F = mean difference between blood-absorbed doses + 1.96 SD; G = mean difference between blood-absorbed doses − 1.96 SD.

    • Doses are in mGy.

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Journal of Nuclear Medicine Technology: 51 (4)
Journal of Nuclear Medicine Technology
Vol. 51, Issue 4
December 1, 2023
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Investigation of the Importance of Applying Various Methods of Calculation in Determining the Blood-Absorbed Dose for Patients with Differentiated Thyroid Carcinoma
Issa A. Al-Shakhrah
Journal of Nuclear Medicine Technology Dec 2023, 51 (4) 296-301; DOI: 10.2967/jnmt.122.265214

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Investigation of the Importance of Applying Various Methods of Calculation in Determining the Blood-Absorbed Dose for Patients with Differentiated Thyroid Carcinoma
Issa A. Al-Shakhrah
Journal of Nuclear Medicine Technology Dec 2023, 51 (4) 296-301; DOI: 10.2967/jnmt.122.265214
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