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Research ArticleClinical Investigation

Posttreatment Exposure Rates for 90Y-Microsphere Patients: A Comparison of Products

Steven Blum, Eugenio Silvestrini, Jonathan Weinstein and Craig Greben
Journal of Nuclear Medicine Technology March 2023, 51 (1) 60-62; DOI: https://doi.org/10.2967/jnmt.122.264335
Steven Blum
1Hofstra University, Hempstead, New York;
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Eugenio Silvestrini
2Radiation Safety, Department of Radiology, Northwell Health, Manhasset, New York;
3Department of Physics and Astronomy, Hofstra University, Hempstead, New York; and
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Jonathan Weinstein
4Donald and Barbara Zucker School of Medicine, Northwell Health, Hofstra University, Hempstead, New York
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Craig Greben
4Donald and Barbara Zucker School of Medicine, Northwell Health, Hofstra University, Hempstead, New York
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Abstract

There has been a significant increase in the use of 90Y-microspheres in treating liver malignancies. This increase could be seen over the last 30 y, and Food and Drug Administration approval of 2 products—Sirtex SIR-Spheres and Boston Scientific TheraSphere—has helped in the proliferation of these treatments. As the increase in use of both products rose at our institution, there was a need to determine whether there should be special considerations for patients who receive one product compared with patients who receive the other product. This determination was made by measuring exposure rates for several regions of the patient before and after implantation. An independent-samples t test analysis (ɑ = 0.05) was performed for 50 patients (25 TheraSphere and 25 SIR-Spheres) to determine whether the products behaved similarly to the extent that exposure to others was minimized and that as-low-as-reasonably-achievable principles were kept. The results showed that the products exhibited no significant differences in exposure rates, suggesting that no special considerations are needed for the procedure for one product compared with the other.

  • yttrium-90
  • 90Y
  • 90Y-microspheres
  • TheraSphere
  • SIR-Spheres

Footnotes

  • Published online Aug. 30, 2022.

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Journal of Nuclear Medicine Technology: 51 (1)
Journal of Nuclear Medicine Technology
Vol. 51, Issue 1
March 1, 2023
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Posttreatment Exposure Rates for 90Y-Microsphere Patients: A Comparison of Products
Steven Blum, Eugenio Silvestrini, Jonathan Weinstein, Craig Greben
Journal of Nuclear Medicine Technology Mar 2023, 51 (1) 60-62; DOI: 10.2967/jnmt.122.264335

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Posttreatment Exposure Rates for 90Y-Microsphere Patients: A Comparison of Products
Steven Blum, Eugenio Silvestrini, Jonathan Weinstein, Craig Greben
Journal of Nuclear Medicine Technology Mar 2023, 51 (1) 60-62; DOI: 10.2967/jnmt.122.264335
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Keywords

  • yttrium-90
  • 90Y
  • 90Y-microspheres
  • TheraSphere
  • SIR-Spheres
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