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Journal of Nuclear Medicine Technology

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Research ArticleClinical Investigation

Safety and Efficacy of 90Y Selective Internal Radiation Therapy Using Glass Microspheres in Hepatocellular Carcinoma: A Southeast Asian Single-Institution Initial Experience

Cherie Wei Qi Ng, Muhammad Jai bin Hassan, Charles Goh, Aaron Kian Ti Tong, Wei Ying Tham, Sue Ping Thang, Winnie Wing-Chuen Lam, Han Chung Low, Butch M. Magsombol and Kelvin Siu Hoong Loke
Journal of Nuclear Medicine Technology June 2024, 52 (2) 148-151; DOI: https://doi.org/10.2967/jnmt.123.265967
Cherie Wei Qi Ng
1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore; and
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Muhammad Jai bin Hassan
1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore; and
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Charles Goh
1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore; and
2Duke–NUS Graduate Medical School, Singapore, Singapore
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Aaron Kian Ti Tong
1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore; and
2Duke–NUS Graduate Medical School, Singapore, Singapore
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Wei Ying Tham
1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore; and
2Duke–NUS Graduate Medical School, Singapore, Singapore
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Sue Ping Thang
1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore; and
2Duke–NUS Graduate Medical School, Singapore, Singapore
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Winnie Wing-Chuen Lam
1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore; and
2Duke–NUS Graduate Medical School, Singapore, Singapore
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Han Chung Low
1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore; and
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Butch M. Magsombol
1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore; and
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Kelvin Siu Hoong Loke
1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore; and
2Duke–NUS Graduate Medical School, Singapore, Singapore
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Abstract

Our objective was to demonstrate primarily the safety and secondarily the efficacy of 90Y glass microspheres in selective internal radiation therapy (SIRT) for hepatocellular carcinoma (HCC) in a local Southeast Asian hospital. Methods: Eleven consecutive patients with small, unresectable, nonmetastatic HCC and referred for locoregional therapy with SIRT with a curative intention were followed up for 6 mo after the procedure by way of interviews, blood tests, and anatomic scans. Results: Although 5 patients had deranged liver function tests after the procedure, in only 1 patient did this constitute a grade 1 toxicity (in alkaline phosphatase) by the Common Terminology Criteria for Adverse Events. Half the patients showed a reduction in serum α-fetoprotein measurements, and 6 of 11 patients demonstrated an objective response (complete or partial) on imaging. Conclusion: SIRT with 90Y glass microspheres is a safe and efficacious locoregional therapy for unresectable HCC. There are similar articles published in the West; however, the patient population there comprises far fewer Asians and the underlying cause for HCC is different from that in the Asian population. Despite these differences, SIRT is an equally effective and safe option for such patients.

  • hepatocellular carcinoma
  • selective internal radiation therapy
  • 90Y

Footnotes

  • Published online Jan. 9, 2024.

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Journal of Nuclear Medicine Technology: 52 (2)
Journal of Nuclear Medicine Technology
Vol. 52, Issue 2
June 1, 2024
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Safety and Efficacy of 90Y Selective Internal Radiation Therapy Using Glass Microspheres in Hepatocellular Carcinoma: A Southeast Asian Single-Institution Initial Experience
Cherie Wei Qi Ng, Muhammad Jai bin Hassan, Charles Goh, Aaron Kian Ti Tong, Wei Ying Tham, Sue Ping Thang, Winnie Wing-Chuen Lam, Han Chung Low, Butch M. Magsombol, Kelvin Siu Hoong Loke
Journal of Nuclear Medicine Technology Jun 2024, 52 (2) 148-151; DOI: 10.2967/jnmt.123.265967

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Safety and Efficacy of 90Y Selective Internal Radiation Therapy Using Glass Microspheres in Hepatocellular Carcinoma: A Southeast Asian Single-Institution Initial Experience
Cherie Wei Qi Ng, Muhammad Jai bin Hassan, Charles Goh, Aaron Kian Ti Tong, Wei Ying Tham, Sue Ping Thang, Winnie Wing-Chuen Lam, Han Chung Low, Butch M. Magsombol, Kelvin Siu Hoong Loke
Journal of Nuclear Medicine Technology Jun 2024, 52 (2) 148-151; DOI: 10.2967/jnmt.123.265967
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Keywords

  • hepatocellular carcinoma
  • selective internal radiation therapy
  • 90Y
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