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Research ArticleQuality & Practice Management

90Y SIR-Spheres Activity Measurement with New SIROS D-Vial Delivery Kit

Benjamin P. Lopez and S. Cheenu Kappadath
Journal of Nuclear Medicine Technology September 2024, 52 (3) 256-260; DOI: https://doi.org/10.2967/jnmt.124.267413
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Benjamin P. Lopez
Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas
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S. Cheenu Kappadath
Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas
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Abstract

A new 90Y SIR-Spheres delivery kit (SIROS D-vial and shield) has been introduced with a different physical form from the legacy V-Vial kit. Here, we establish the dose calibrator settings and exposure-rate–to–activity conversion factor to assay 90Y SIR-Spheres activity in the new SIROS kit. Methods: Eight D-vials with initial 90Y activities from 1.2 to 6.6 GBq within acrylic shields were assayed with dose calibrators and exposure-rate meters until activities decayed to approximately 0.1 GBq. The dose calibrator settings resulting in the lowest median activity errors and the best-fit slope of exposure rate versus activity were identified. Results: SIROS D-vial 90Y activity can be accurately and reliably estimated directly using setting 51 × 10 on both the CRC-15R and the CRC-55tR dose calibrators (errors within ±0.5%) and indirectly with an exposure-rate reading at 30 cm using conversion factor 0.664 ± 0.003 GBq/(mR/h) (R2 = 0.985). Conclusion: Dose calibrator settings and exposure-rate–to–activity conversion factor for 90Y activity assays with new SIROS kit should be updated from legacy V-Vial parameters to avoid an approximately 10% underestimation.

  • 90Y microspheres
  • SIROS
  • SIR-Spheres
  • dose calibrator
  • ionization chamber

Footnotes

  • Published online Jul. 17, 2024.

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Journal of Nuclear Medicine Technology: 52 (3)
Journal of Nuclear Medicine Technology
Vol. 52, Issue 3
September 1, 2024
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90Y SIR-Spheres Activity Measurement with New SIROS D-Vial Delivery Kit
Benjamin P. Lopez, S. Cheenu Kappadath
Journal of Nuclear Medicine Technology Sep 2024, 52 (3) 256-260; DOI: 10.2967/jnmt.124.267413
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Keywords

  • 90Y microspheres
  • SIROS
  • SIR-Spheres
  • dose calibrator
  • ionization chamber
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90Y SIR-Spheres Activity Measurement with New SIROS D-Vial Delivery Kit
Benjamin P. Lopez, S. Cheenu Kappadath
Journal of Nuclear Medicine Technology Sep 2024, 52 (3) 256-260; DOI: 10.2967/jnmt.124.267413

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