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Research ArticleImaging

Optimization of the Attenuation Coefficient for Chang Attenuation Correction in 123I Brain Perfusion SPECT

Taisuke Murata, Yuri Hayashi, Masahisa Onoguchi, Takayuki Shibutani, Takashi Iimori, Koichi Sawada, Tetsuro Umezawa, Yoshitada Masuda and Takashi Uno
Journal of Nuclear Medicine Technology March 2023, 51 (1) 49-56; DOI: https://doi.org/10.2967/jnmt.122.264990
Taisuke Murata
1Department of Radiology, Chiba University Hospital, Chiba, Japan;
2Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan; and
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Yuri Hayashi
1Department of Radiology, Chiba University Hospital, Chiba, Japan;
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Masahisa Onoguchi
2Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan; and
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Takayuki Shibutani
2Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan; and
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Takashi Iimori
1Department of Radiology, Chiba University Hospital, Chiba, Japan;
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Koichi Sawada
1Department of Radiology, Chiba University Hospital, Chiba, Japan;
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Tetsuro Umezawa
1Department of Radiology, Chiba University Hospital, Chiba, Japan;
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Yoshitada Masuda
1Department of Radiology, Chiba University Hospital, Chiba, Japan;
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Takashi Uno
3Department of Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
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Abstract

N-isopropyl-p-123I-iodoamphetamine brain perfusion SPECT has been used with various attenuation coefficients (μ-values); however, optimization is required. This study aimed to determine the optimal μ-value (μopt-value) for Chang attenuation correction (AC) using clinical data by comparing the Chang method and CT-based AC. Methods: We used 100 patients (reference group, 60; disease group, 40) who underwent N-isopropyl-p-123I-iodoamphetamine SPECT. SPECT images of the reference group were obtained to calculate the AC using the Chang method (μ-values, 0.07–0.20; 0.005 interval) and the CT-based method, both without scatter correction (SC) and with SC. The μopt-value with the smallest mean percentage error for the brain regions of the reference group was calculated. Agreement between the Chang and CT-based methods applying the μopt-value was evaluated using Bland–Altman analysis. Additionally, the percentage error in the region of hypoperfusion in the diseased group was compared with the percentage error in the same region in the reference group when the μopt-value was applied. Results: The μopt-values were 0.140 for Chang without SC and 0.160 for Chang with SC. In the Chang method, with the μopt-value applied, fixed and proportional biases were observed in the Bland–Altman analysis (both P < 0.05), and there was a tendency for the percentage error to be underestimated in the limbic regions and overestimated in the central brain regions. There was no significant difference between the disease group and the reference group in the region of hypoperfusion in either Chang without SC or Chang with SC. Conclusion: The present study revealed that the μopt-values of the Chang method are 0.140 without SC and 0.160 with SC.

  • SPECT
  • brain perfusion
  • Chang attenuation correction
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Journal of Nuclear Medicine Technology: 51 (1)
Journal of Nuclear Medicine Technology
Vol. 51, Issue 1
March 1, 2023
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Optimization of the Attenuation Coefficient for Chang Attenuation Correction in 123I Brain Perfusion SPECT
Taisuke Murata, Yuri Hayashi, Masahisa Onoguchi, Takayuki Shibutani, Takashi Iimori, Koichi Sawada, Tetsuro Umezawa, Yoshitada Masuda, Takashi Uno
Journal of Nuclear Medicine Technology Mar 2023, 51 (1) 49-56; DOI: 10.2967/jnmt.122.264990

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Optimization of the Attenuation Coefficient for Chang Attenuation Correction in 123I Brain Perfusion SPECT
Taisuke Murata, Yuri Hayashi, Masahisa Onoguchi, Takayuki Shibutani, Takashi Iimori, Koichi Sawada, Tetsuro Umezawa, Yoshitada Masuda, Takashi Uno
Journal of Nuclear Medicine Technology Mar 2023, 51 (1) 49-56; DOI: 10.2967/jnmt.122.264990
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Keywords

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