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Research ArticleImaging

The Complementary Role of 68Ga-DOTATATE PET/CT in Diagnosis of Recurrent Meningioma

Min J. Kong, Aaron F. Yang, Sujay A. Vora, Jeffrey S. Ross and Ming Yang
Journal of Nuclear Medicine Technology December 2022, 50 (4) 348-352; DOI: https://doi.org/10.2967/jnmt.122.263949
Min J. Kong
1Department of Radiology, Mayo Clinic, Scottsdale, Arizona; and
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Aaron F. Yang
1Department of Radiology, Mayo Clinic, Scottsdale, Arizona; and
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Sujay A. Vora
2Department of Radiation Oncology, Mayo Clinic, Scottsdale, Arizona
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Jeffrey S. Ross
1Department of Radiology, Mayo Clinic, Scottsdale, Arizona; and
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Ming Yang
1Department of Radiology, Mayo Clinic, Scottsdale, Arizona; and
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  • FIGURE 1.
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    FIGURE 1.

    Multiple variable-sized, dura-based enhancing lesions exhibit somatostatin receptor positivity on 68Ga-DOTATATE PET/CT. One tracer-avid bone marrow focus on right frontal bone is concerning for meningioma transosseous infiltration (arrows). Maximum-intensity projection exhibits extensive tumor burden of recurrent meningioma. Shown are CE MR image (A), 68Ga-DOTATATE PET image (B), low-dose CT image (C), PET/MR image (D), PET/CT image (E), and PET maximum-intensity projection (F).

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    FIGURE 2.

    68Ga-DOTATATE PET/CT/MRI series, adapted for radiation therapy planning for proton bean therapy, showed enhancing lesions centered at right temporal craniectomy site, indicating residual tumor after subtotal resection. Three-year follow-up CE MRI showed deceased size of tumor, indicating favorable response to radiation therapy. F/u = follow-up.

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    FIGURE 3.

    In 68Ga-DOTATATE PET/CT/MRI series, CE MRI demonstrated enhancing focus at parietal vertex, which exhibited PET avidity (red arrows). PET/CT was able to identify another PET-avid focus at parasagittal left frontal region, indicative of recurrence (green arrows).

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    TABLE 1.

    Demography of Meningioma Patients

    Patient no.SexWHO gradeAge (y)Initial locationOnsetTreatment historyPET/CT time (y)PET/CT findingsFollow-up therapyOutcome
    1F169Right frontal2005Craniotomy × 3, CyberKnife embolization12PositiveBevacizumab, octreotideDied
    2F282Right sphenoid2016Craniotomy × 21Positive × 2Proton beam therapySurvived
    3M272Bifrontal2009Craniotomy × 3, radiation therapy8PositiveOctreotideDied
    4M259Left skull base2008γ-knife10PositiveOctreotideDied
    5M277Bifrontal2012Radiosurgery, craniotomy × 27PositiveOctreotide, bevacizumabDied
    6M272Left frontoparietal2015Craniotomy × 1, radiation therapy3PositiveProton beam therapySurvived
    7F347Right frontal2008Craniotomy × 112Negative × 2SurveillanceSurvived
    8F168Right skull base2021Partial resection1PositiveRadiation therapySurvived
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Journal of Nuclear Medicine Technology: 50 (4)
Journal of Nuclear Medicine Technology
Vol. 50, Issue 4
December 1, 2022
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The Complementary Role of 68Ga-DOTATATE PET/CT in Diagnosis of Recurrent Meningioma
Min J. Kong, Aaron F. Yang, Sujay A. Vora, Jeffrey S. Ross, Ming Yang
Journal of Nuclear Medicine Technology Dec 2022, 50 (4) 348-352; DOI: 10.2967/jnmt.122.263949

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The Complementary Role of 68Ga-DOTATATE PET/CT in Diagnosis of Recurrent Meningioma
Min J. Kong, Aaron F. Yang, Sujay A. Vora, Jeffrey S. Ross, Ming Yang
Journal of Nuclear Medicine Technology Dec 2022, 50 (4) 348-352; DOI: 10.2967/jnmt.122.263949
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Keywords

  • meningioma
  • somatostatin receptor
  • DOTATATE
  • octreotide
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