PT  - JOURNAL ARTICLE
AU  - Min J. Kong
AU  - Aaron F. Yang
AU  - Sujay A. Vora
AU  - Jeffrey S. Ross
AU  - Ming Yang
TI  - The Complementary Role of <sup>68</sup>Ga-DOTATATE PET/CT in Diagnosis of Recurrent Meningioma
AID  - 10.2967/jnmt.122.263949
DP  - 2022 Dec 01
TA  - Journal of Nuclear Medicine Technology
PG  - 348--352
VI  - 50
IP  - 4
4099  - http://tech.snmjournals.org/content/50/4/348.short
4100  - http://tech.snmjournals.org/content/50/4/348.full
SO  - J. Nucl. Med. Technol.2022 Dec 01; 50
AB  - Contrast-enhanced brain MRI is the imaging modality of choice in diagnosis and posttreatment evaluation, but its role is limited in distinguishing recurrent lesions from postoperative changes. 68Ga-DOTATATE is a somatostatin analog PET tracer that has high affinity to meningioma expressing somatostatin receptor. Methods: In this case series review, we describe 8 patients with brain MRI showing suspected recurrent meningioma who underwent focused 68Ga-DOTATATE PET/CT for radiation treatment planning. Results: The combined brain MRI and PET/CT improved the conspicuity of the lesions and aided radiation treatment planning. The time from the initial surgery to PET/CT varied widely, ranging from 1 to 12 y. Three patients underwent PET/CT shortly after the initial surgery (1–3 y) and underwent targeted radiation therapy. Subsequent imaging showed no evidence of recurrence. Four patients had a prolonged time between the PET/CT and the initial surgery (7–12 y), which showed an extensive tumor burden. All 4 patients died shortly after the last PET/CT scan. Conclusion: 68Ga-DOTATATE PET shows a promising complementary role in detection and treatment planning of recurrent meningioma.