RT Journal Article SR Electronic T1 The Complementary Role of 68Ga-DOTATATE PET/CT in Diagnosis of Recurrent Meningioma JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 348 OP 352 DO 10.2967/jnmt.122.263949 VO 50 IS 4 A1 Min J. Kong A1 Aaron F. Yang A1 Sujay A. Vora A1 Jeffrey S. Ross A1 Ming Yang YR 2022 UL http://tech.snmjournals.org/content/50/4/348.abstract AB Contrast-enhanced brain MRI is the imaging modality of choice in diagnosis and posttreatment evaluation, but its role is limited in distinguishing recurrent lesions from postoperative changes. 68Ga-DOTATATE is a somatostatin analog PET tracer that has high affinity to meningioma expressing somatostatin receptor. Methods: In this case series review, we describe 8 patients with brain MRI showing suspected recurrent meningioma who underwent focused 68Ga-DOTATATE PET/CT for radiation treatment planning. Results: The combined brain MRI and PET/CT improved the conspicuity of the lesions and aided radiation treatment planning. The time from the initial surgery to PET/CT varied widely, ranging from 1 to 12 y. Three patients underwent PET/CT shortly after the initial surgery (1–3 y) and underwent targeted radiation therapy. Subsequent imaging showed no evidence of recurrence. Four patients had a prolonged time between the PET/CT and the initial surgery (7–12 y), which showed an extensive tumor burden. All 4 patients died shortly after the last PET/CT scan. Conclusion: 68Ga-DOTATATE PET shows a promising complementary role in detection and treatment planning of recurrent meningioma.