Research ArticleBasic Science Investigation

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites After 177Lu-DOTATATE Infusion

Sameer Tipnis, William J. Rieter, Vladimir Henderson-Suite and Leonie Gordon
Journal of Nuclear Medicine Technology September 2022, 50 (3) 274-277; DOI: https://doi.org/10.2967/jnmt.121.262820

Article Figures & Data

Figures

  • Figure
  • FIGURE 1.
    FIGURE 1.

    A 59 y old with metastatic ileocecal carcinoid tumor. (A) Anterior 68Ga-DOTATATE PET maximum-intensity-projection image showing intense somatostatin receptor avidity greater than that of the liver within a conglomerate of central abdominal lymph nodes. Axial contrast-enhanced CT images of abdomen with fused PET/CT images at same level illustrating examples of retroperitoneal (B and C) and central mesenteric lymph nodes (D and E) (arrows) that showed somatostatin receptor positivity on PET/CT. Scale bars = SUVmax = 14.

  • FIGURE 2.
    FIGURE 2.

    Plot of 177Lu activity concentration in ascitic fluid as function of time. Estimated effective half-life in ascitic fluid is 2.9 d.

Tables

  • TABLE 1.

    Principal Emissions for 177Lu and Their Relative Intensities (Those > 1%)

    RadiationEnergy (keV)I (%)
    β−176.512.2
    β−384.99.1
    β−497.878.6
    γ112.96.4
    γ208.411.0

    • I (%) = intensity percentage.

    • Half-life of 177Lu = 6.7 D.

  • TABLE 2.

    Mean Activity Concentration Based on Liquid Scintillation Measurements of Ascitic Fluid Samples Obtained at Various Intervals After Treatment Doses of 177Lu-DOTATATE

    Postinfusion dayActivity concentration (Bq/mL)
    Treatment 1 (n = 5)Treatment 2 (n = 10)Treatment 3 (n = 10)Mean
    3194.3 ± 15.5190.2 ± 17.8141.3 ± 10.7175.3 ± 25.9
    7——59.6 ± 5.659.6 ± 5.6
    1022.2 ± 2.224.80 ± 3.329.6 ± 2.625.5 ± 4.8
    13—11.1 ± 2.613.7 ± 1.512.4 ± 3.0
    20—3.0 ± 0.4—3.0 ± 0.4
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