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Research ArticleBrief Communication

68Ga-Pentixafor PET/CT Demonstrating In Vivo CXCR4 Receptor Overexpression in Rare Lung Malignancies: Correlation with Histologic and Histochemical Findings

Ankit Watts, Baljinder Singh, Harmandeep Singh, Harneet Kaur, Amanjit Bal, Mehak Vohra, Sunil K. Arora and D. Behera
Journal of Nuclear Medicine Technology September 2022, 50 (3) 278-281; DOI: https://doi.org/10.2967/jnmt.122.264141
Ankit Watts
1Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;
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Baljinder Singh
1Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;
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Harmandeep Singh
1Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;
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Harneet Kaur
1Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;
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Amanjit Bal
2Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;
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Mehak Vohra
3Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; and
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Sunil K. Arora
3Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; and
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D. Behera
4Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Abstract

68Ga-pentixafor PET/CT imaging allows noninvasive assessment of C-X-C chemokine receptor type 4 (CXCR4) expression in various malignancies, but its use in rare lung cancer variants has not been reported. Methods: 68Ga-pentixafor PET/CT imaging was performed on 6 patients (3 men, 3 women; mean age, 57.0 ± 16.8 y) with suspected lung masses. Whole-body PET/CT images were acquired 1 h after intravenous injection of 148.0–185.0 MBq of the tracer. PET/CT images were reconstructed and analyzed. The image findings were correlated with histopathologic and quantitative (CXCR4) fluorescence-activated cell sorting analysis. Results: Histopathologic diagnosis of hemangioendothelioma, sarcomatoid carcinoma, and hemangiopericytoma was confirmed in 1 patient each. Lung metastasis was diagnosed in the remaining 3 of 6 patients with primary sarcoma (n = 1), renal cell carcinoma (n = 1), and unknown primary (n = 1). Increased uptake in the primary lung mass, with an SUVmax of 3.0, 6.34, and 13.0, was noted in the hemangiopericytoma, sarcomatoid carcinoma and hemangioendothelioma cases, respectively. The mean SUVmax, mean fluorescence intensity, and percentage of stained cells were highest in hemangioendothelioma. Among 3 patients with lung metastases, the highest SUVmax, 9.5, was in the primary sarcoma patient. Conclusion: 68Ga-pentixafor selectively targets the in vivo whole-body disease burden of CXCR4 receptors. This approach thus holds promise for developing suitable radiotheranostics for lung cancers expressing these targets.

  • [68Ga]pentixafor
  • PET/CT imaging
  • CXCR4 receptors
  • lung cancer
  • rare variants
  • metastasis

Footnotes

  • Published online May 24, 2022.

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Journal of Nuclear Medicine Technology: 50 (3)
Journal of Nuclear Medicine Technology
Vol. 50, Issue 3
September 1, 2022
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68Ga-Pentixafor PET/CT Demonstrating In Vivo CXCR4 Receptor Overexpression in Rare Lung Malignancies: Correlation with Histologic and Histochemical Findings
Ankit Watts, Baljinder Singh, Harmandeep Singh, Harneet Kaur, Amanjit Bal, Mehak Vohra, Sunil K. Arora, D. Behera
Journal of Nuclear Medicine Technology Sep 2022, 50 (3) 278-281; DOI: 10.2967/jnmt.122.264141

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68Ga-Pentixafor PET/CT Demonstrating In Vivo CXCR4 Receptor Overexpression in Rare Lung Malignancies: Correlation with Histologic and Histochemical Findings
Ankit Watts, Baljinder Singh, Harmandeep Singh, Harneet Kaur, Amanjit Bal, Mehak Vohra, Sunil K. Arora, D. Behera
Journal of Nuclear Medicine Technology Sep 2022, 50 (3) 278-281; DOI: 10.2967/jnmt.122.264141
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Keywords

  • [68Ga]pentixafor
  • PET/CT imaging
  • CXCR4 receptors
  • lung cancer
  • rare variants
  • Metastasis
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