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Research ArticleRadiation Safety

Radiation Dose to Medical Staff from Administering 177Lu-PSMA-DKFZ-617 Therapy

Elahe Mahmoudi, Elahe Pirayesh, Mohammad Reza Deevband, Mahasti Amoui, Mohammadali Ghodsi Rad, Mehrdad Ghorbani Rad and Mahdi Ghorbani
Journal of Nuclear Medicine Technology September 2022, 50 (3) 269-273; DOI: https://doi.org/10.2967/jnmt.121.263135
Elahe Mahmoudi
1Biomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
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Elahe Pirayesh
2Nuclear Medicine Department, Shohadaye Tajrish Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; and
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Mohammad Reza Deevband
1Biomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
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Mahasti Amoui
2Nuclear Medicine Department, Shohadaye Tajrish Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; and
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Mohammadali Ghodsi Rad
2Nuclear Medicine Department, Shohadaye Tajrish Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; and
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Mehrdad Ghorbani Rad
3Nuclear Medicine Department, Shohadaye Tajrish Hospital, Tehran, Iran
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Mahdi Ghorbani
1Biomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
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    TABLE 1.

    Demographic Information on Staff

    StaffFemale (n)Male (n)Distance
    Technologist in charge of injection440 m (injecting radiopharmaceutical)
    Technologist in charge of imaging440.25 m (positioning patient);1 m (presenting information to patient)
    Nurse222 m (monitoring treatment process)
    Physicist222 m (providing protection guidelines)
    Physician310.25 m (checking patient’s vital signs)
    • View popup
    TABLE 2.

    Mean Dose Rates (μSv/[h⋅GBq]) and Related SDs at Various Distances from Patient and Various Times

    Distance (m)
    Time (h)00.250.512
    078.6 ± 5.0 (72.7–87.5)47.5 ± 2.0 (40.0–58.0)21.5 ± 1.2 (18.5–24.5)7.1 ± 0.3 (5.5–8.3)5.4 ± 0.5 (4.4–7.2)
    170.3 ± 3.0 (63.6–78.1)36.3 ± 3.1 (32.0–44.6)19.1 ± 1.5 (16.8–21.3)6.0 ± 0.5 (4.4–6.6)3.6 ± 0.4 (2.8–4.5)
    253.0 ± 3.4 (55.0–44.9)32.3 ± 1.1 (24.3–34.4)16.5 ± 1.1 (12.4–18.4)5.1 ± 0.6 (3.4–5.5)2.6 ± 0.3 (2.0–3.1)
    344.5 ± 3.0 (35.7–47.3)24.3 ± 1.2 (18.8–27.9)12.6 ± 1.3 (7.7–14.4)4.2 ± 0.2 (2.7–4.7)2.3 ± 0.2 (1.6–2.7)
    434.4 ± 1.5 (29.9–39.5)17.2 ± 1.6 (14.6–19.7)8.5 ± 1.7 (6.5–10.8)3.2 ± 0.3 (2.4–3.9)1.8 ± 0.2 (1.4–2.4)
    524.2 ± 1.5 (19.0–27.3)13.3 ± 0.9 (10.9–14.9)6.1 ± 0.3 (5.5–7.6)2.8 ± 0.2 (1.9–3.2)1.3 ± 0.3 (0.8–1.8)
    622.2 ± 1.3 (17.0–25.5)11.5 ± 0.5 (8.8–14.0)5.5 ± 0.2 (5.0–7.0)2.2 ± 0.3 (1.2–3.0)1.0 ± 0.5 (0.5–1.5)
    1817.5 ± 1.1 (15.2–20.4)10.5 ± 0.7 (7.9–11.9)5.0 ± 0.4 (3.7–5.9)1.4 ± 0.3 (0.9–1.7)0.8 ± 0.2 (0.3–1.0)
    2413.5 ± 1.3 (12.4–16.2)6.5 ± 1.1 (5.9–8.0)3.1 ± 0.2 (2.9–3.5)1.0 ± 0.04 (0.5–1.4)0.5 ± 0.02 (0.3–0.8)
    3610.0 ± 1.1 (8.4–13.3)4.5 ± 1.0 (3.8–6.0)2.3 ± 0.3 (1.8–3.0)0.6 ± 0.03 (0.3–1.0)0.3 ± 0.03 (0.1–0.8)
    • Data are mean ± SD.

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    TABLE 3.

    Total Dose to Staff per Patient

    Without lead shieldWith lead shield
    StaffMinimum per patient (μSv)Maximum per patient (μSv)Mean ± SDMinimum per patient (μSv)Maximum per patient (μSv)Mean ± SDP
    Technologist in charge of injection6.58.67.6 ± 1.14.05.24.8 ± 0.9≤0.05
    Technologist in charge of imaging3.75.04.0 ± 0.52.13.02.4 ± 0.3≤0.05
    Physician3.03.63.3 ± 0.31.62.11.8 ± 0.4<0.05
    Physicist3.24.23.5 ± 0.51.72.52.2 ± 0.3<0.05
    Nurse7.49.28.1 ± 0.84.25.75.2 ± 0.3≤0.05
    • View popup
    TABLE 4.

    Estimated Mean Annual Dose to Staff With and Without Shielding

    StaffWith lead shield (mSv)Without lead shield (mSv)
    Technologist in charge of injection2.23.4
    Technologist in charge of imaging1.52.6
    Physician1.01.8
    Physicist1.22.1
    Nurse2.33.8
    • View popup
    TABLE 5.

    Mean Annual Dose to Staff as Measured with Thermoluminescent Dosimeters

    StaffMaximum (mSv)Minimum (mSv)Mean without lead shield (mSv)
    Technologist in charge of injection4.93.64.6
    Technologist in charge of imaging3.52.43.1
    Physician1.81.31.6
    Physicist2.21.61.9
    Nurse4.83.84.3
    • View popup
    TABLE 6.

    Comparison of Mean Dose (μSv per patient) from Current Study and from Another International Study

    StaffDemire et al. (7)Current study without lead shieldCurrent study with lead shield
    Radiopharmacist4.07.6 ± 1.14.8 ± 0.9
    Physicist2.04.0 ± 0.52.4 ± 0.3
    Physician2.03.3 ± 0.31.8 ± 0.4
    Technologist3.03.5 ± 0.52.2 ± 0.3
    Nurse6.08.1 ± 0.85.2 ± 0.3
    • ± SD is also shown for current study.

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Journal of Nuclear Medicine Technology: 50 (3)
Journal of Nuclear Medicine Technology
Vol. 50, Issue 3
September 1, 2022
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Radiation Dose to Medical Staff from Administering 177Lu-PSMA-DKFZ-617 Therapy
Elahe Mahmoudi, Elahe Pirayesh, Mohammad Reza Deevband, Mahasti Amoui, Mohammadali Ghodsi Rad, Mehrdad Ghorbani Rad, Mahdi Ghorbani
Journal of Nuclear Medicine Technology Sep 2022, 50 (3) 269-273; DOI: 10.2967/jnmt.121.263135

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Radiation Dose to Medical Staff from Administering 177Lu-PSMA-DKFZ-617 Therapy
Elahe Mahmoudi, Elahe Pirayesh, Mohammad Reza Deevband, Mahasti Amoui, Mohammadali Ghodsi Rad, Mehrdad Ghorbani Rad, Mahdi Ghorbani
Journal of Nuclear Medicine Technology Sep 2022, 50 (3) 269-273; DOI: 10.2967/jnmt.121.263135
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