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Research ArticleSpecial Contribution

Nuclear Medicine and Molecular Imaging in Nodal Staging and Surveillance of Ocular Melanoma: Case Reports and Review of the Literature

Kenneth S. Zurcher, Odette M. Houghton, Joanne F. Shen, Mahesh Seetharam, Michael C. Roarke and Ming Yang
Journal of Nuclear Medicine Technology September 2021, 49 (3) 275-280; DOI: https://doi.org/10.2967/jnmt.120.260539
Kenneth S. Zurcher
1Department of Radiology, Mayo Clinic, Scottsdale, Arizona;
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Odette M. Houghton
2Department of Ophthalmology, Mayo Clinic, Scottsdale, Arizona; and
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Joanne F. Shen
2Department of Ophthalmology, Mayo Clinic, Scottsdale, Arizona; and
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Mahesh Seetharam
3Department of Hematology/Oncology, Mayo Clinic, Scottsdale, Arizona
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Michael C. Roarke
1Department of Radiology, Mayo Clinic, Scottsdale, Arizona;
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Ming Yang
1Department of Radiology, Mayo Clinic, Scottsdale, Arizona;
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    FIGURE 1.

    Whole-body 18F-FDG PET/MRI study in surveillance of UM (case 1). Whole-body maximal-intensity-projection (MIP) images exhibit tracer-avid left eye lesion and numerous tracer-avid lesions in liver. Axial 18F-FDG PET/MRI of left eye demonstrates high T1-signal lesion in left globe with increased tracer uptake, with SUVmax of 8.3 (top line on MIP image; top row of images). On representative layer of liver (bottom line on MIP image; bottom 2 rows of images), multiple liver lesions with variable low and high T1 signals show increased uptake, with SUVmax of 4.0–11.7. In addition, diffusion-weighted imaging (DWI) shows more small metastases with restricted diffusion (arrows) than does contrast-enhanced T1-weighted MRI (T1C+) or PET. T1C− = non–contrast-enhanced T1-weighted MRI; T2 = T2-weighted MRI. Color version of this figure is available as supplemental file at http://tech.snmjournals.org.

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    FIGURE 2.

    99mTc-filtered sulfur colloid SPECT/CT (case 2). (A) Coronal PET/MR image demonstrating successful radiotracer injection to right-eye subconjunctival region by ophthalmologist. (B) Axial PET/MR image. (C) Axial low-dose CT image. Tiny sentinel lymph node (arrows) was identified in right fossa of parotid gland. Node was negative for metastasis on biopsy. Color version of this figure is available as supplemental file at http://tech.snmjournals.org.

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    FIGURE 3.

    Whole-body maximum-intensity-projection 18F-FDG PET/CT and 18F-FDG PET/MRI in surveillance of CM (case 2). Consecutive anterior and right lateral views do not demonstrate hypermetabolic metastasis or recurrence at baseline or at the first (12 mo) or second (16 mo) follow-up (F/u-1 and F/u-2, respectively).

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    FIGURE 4.

    Illustration of eye anatomy. UM occurs at iris, ciliary body, and choroid. CM occurs at palpebral and bulbar conjunctiva. (Reprinted with permission of (38).) Color version of this figure is available as supplemental file at http://tech.snmjournals.org.

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Journal of Nuclear Medicine Technology: 49 (3)
Journal of Nuclear Medicine Technology
Vol. 49, Issue 3
September 1, 2021
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Nuclear Medicine and Molecular Imaging in Nodal Staging and Surveillance of Ocular Melanoma: Case Reports and Review of the Literature
Kenneth S. Zurcher, Odette M. Houghton, Joanne F. Shen, Mahesh Seetharam, Michael C. Roarke, Ming Yang
Journal of Nuclear Medicine Technology Sep 2021, 49 (3) 275-280; DOI: 10.2967/jnmt.120.260539

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Nuclear Medicine and Molecular Imaging in Nodal Staging and Surveillance of Ocular Melanoma: Case Reports and Review of the Literature
Kenneth S. Zurcher, Odette M. Houghton, Joanne F. Shen, Mahesh Seetharam, Michael C. Roarke, Ming Yang
Journal of Nuclear Medicine Technology Sep 2021, 49 (3) 275-280; DOI: 10.2967/jnmt.120.260539
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