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Research ArticleRadiopharmacy & Adjunctive Medications

Daily Caffeine Consumption Is Associated with Decreased Incidence of Symptoms and Hemodynamic Changes During Pharmacologic Stress with Regadenoson

Michael I. Posch, Matthew D. Kay, Ahmed A. Harhash, Jennifer J. Huang, Elizabeth A. Krupinski, Aiden Abidov, Natalie A. McMillan and Phillip H. Kuo
Journal of Nuclear Medicine Technology March 2020, 48 (1) 73-76; DOI: https://doi.org/10.2967/jnmt.118.225219
Michael I. Posch
1Department of Medical Imaging, University of Arizona, Tucson, Arizona
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Matthew D. Kay
1Department of Medical Imaging, University of Arizona, Tucson, Arizona
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Ahmed A. Harhash
2Department of Medicine, University of Arizona, Tucson, Arizona
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Jennifer J. Huang
2Department of Medicine, University of Arizona, Tucson, Arizona
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Elizabeth A. Krupinski
3Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia; and
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Aiden Abidov
4Department of Medicine, Wayne State University, Detroit, Michigan
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Natalie A. McMillan
1Department of Medical Imaging, University of Arizona, Tucson, Arizona
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Phillip H. Kuo
1Department of Medical Imaging, University of Arizona, Tucson, Arizona
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    TABLE 1

    Patient Characteristics

    CharacteristicTest valuePCaffeine consumersNon–caffeine consumers
    Mean aget = 1.2990.197063.39 (12.34)58.00 (17.77)
    β-blocker useχ2 = 0.7850.375741%27%
    Diabetesχ2 = 0.3230.570137%45%
    Sexχ2 = 3.4040.065057% M27% M
    Mean body weight (kg)t = 1.2640.209385.30 (19.03)92.99 (19.23)
    Mean body mass indext = 2.0410.043929.40 (6.62)33.69 (6.21)
    Coronary artery diseaseχ2 = 0.0680.794431%27%
    Hypertensionχ2 = 0.1570.691687%91%
    Hyperlipidemiaχ2 = 3.5620.059162%91%
    Smokerχ2 = 0.7640.382120%9%
    • Data in parentheses are SDs.

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    TABLE 2

    Symptom Frequency

    SymptomPCaffeine consumersNon–caffeine consumers
    All symptoms0.9579
    Aminophylline use0.037118%45%
    Palpitations0.20532%9%
    Shortness of breath0.497223%30%
    Flushing0.924110%9%
    Chest pain0.001310%45%
    Headache0.271314%27%
    Nausea or vomiting0.821816%18%
    Dizziness0.101820%0%
    Feeling hot0.53873%0%
    Abdominal pain0.271810%0%
    Back pain0.72531%0%
    Dysgeusia0.20532%9%
    • View popup
    TABLE 3

    Mean Physiologic Parameters

    ParameterPCaffeine consumersNon–caffeine consumers
    Arrhythmia0.899534%36%
    Resting HR (bpm)0.049768.76 (12.32)76.82 (15.71)
    Peak HR (bpm)0.031496.52 (16.72)108.00 (13.93)
    HR response (bpm)0.458727.77 (13.80)31.18 (18.73)
    BP response0.365931% hyper/22% hypo20% hyper/10% hypo
    Atrial fibrillation0.35533%9%
    Hypotension0.538797%91%
    Systolic BP response (mm Hg)0.767110.12 (23.10)7.90 (14.37)
    Diastolic BP response (mm Hg)0.04680.24 (10.46)−7.20 (16.06)
    Rest systolic BP (mm Hg)0.4453134.72 (19.89)129.70 (17.19)
    Rest diastolic BP (mm Hg)0.721077.54 (13.14)79.10 (11.88)
    Peak systolic BP (mm Hg)0.3517144.84 (27.28)136.91 (18.82)
    Peak diastolic BP (mm Hg)0.243877.79 (14.72)72.27 (14.83)
    • HR = heart rate; bpm = beats per minute; BP = blood pressure; hyper = hypertensive blood pressure response; hypo = hypotensive blood pressure response.

    • Data in parentheses are SD.

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Journal of Nuclear Medicine Technology: 48 (1)
Journal of Nuclear Medicine Technology
Vol. 48, Issue 1
March 1, 2020
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Daily Caffeine Consumption Is Associated with Decreased Incidence of Symptoms and Hemodynamic Changes During Pharmacologic Stress with Regadenoson
Michael I. Posch, Matthew D. Kay, Ahmed A. Harhash, Jennifer J. Huang, Elizabeth A. Krupinski, Aiden Abidov, Natalie A. McMillan, Phillip H. Kuo
Journal of Nuclear Medicine Technology Mar 2020, 48 (1) 73-76; DOI: 10.2967/jnmt.118.225219

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Daily Caffeine Consumption Is Associated with Decreased Incidence of Symptoms and Hemodynamic Changes During Pharmacologic Stress with Regadenoson
Michael I. Posch, Matthew D. Kay, Ahmed A. Harhash, Jennifer J. Huang, Elizabeth A. Krupinski, Aiden Abidov, Natalie A. McMillan, Phillip H. Kuo
Journal of Nuclear Medicine Technology Mar 2020, 48 (1) 73-76; DOI: 10.2967/jnmt.118.225219
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Keywords

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