Article Figures & Data
Figures
- FIGURE 1.
Distribution of ejection fraction and kinetic parameters of cholecystokinin-stimulated gallbladder emptying in entire patient population. Bars reflect numbers of subjects in each bin, representing sequential 10% of total gallbladder emptying. Shown are conventional measure of gallbladder ejection fraction and key kinetic parameters of average rate over complete period of gallbladder emptying, peak rate of gallbladder emptying achieved, and average rate of gallbladder emptying over first 20 min of cholecystokinin infusion. GB = gallbladder.
- FIGURE 2.
Relationships between gallbladder ejection fraction and kinetic parameters of cholecystokinin-stimulated gallbladder emptying in individuals. Shown are distributions of points representing individual data on left, and distributions of kinetic parameters in patients having gallbladder ejection fractions of at least 80%. In this select group with no demonstrable gallbladder or biliary pathology, there are wide distributions of kinetics, reflecting differences in cholecystokinin responsiveness. EF = ejection fraction; GB = gallbladder.
- FIGURE 3.
Kinetic profiles observed in patients with cholecystokinin-stimulated gallbladder ejection fractions of at least 80%. Profile 1, with earliest peak response, exhibited highest rate of emptying and highest average rate of emptying. Profile 3, with latest peak response, exhibited lowest peak rate and lowest average rate of emptying. Representative profiles are shown. GB = gallbladder.
Tables
- TABLE 1
Characteristics of Study Population and Subgroup Exhibiting Complete Gallbladder Emptying
Overall population Ejection fraction ≥ 80% Characteristic Total Male Female Total Male Female Age (y) 52.8 ± 15.5 (238) 54.0 ± 15.4 (80) 52.2 ± 15.6 (158) 53.2 ± 15.5 (141) 55.4 ± 15.8 (50) 52 ± 15.2 (91) Male (n) 80 80 0 50 50 0 Female (n) 158 0 158 91 0 91 Weight (kg) 77.4 ± 20.8 (233) 91.9 ± 20.7 (77) 70.2 ± 16.8 (156) 76.8 ± 19.9 (140) 89.1 ± 21.3 (50) 70 ± 15.3 (90) Body mass index (kg/m2) 27.1 ± 6.0 (230) 29.0 ± 5.7 (77) 26.2 ± 5.9 (153) 26.9 ± 6.0 (137) 28.4 ± 6.3 (50) 26.1 ± 5.7 (87) Fasting glucose (mg/dL) 99.3 ± 21.2 (200) 104.4 ± 26.4 (64) 96.9 ± 17.9 (136) 97.8 ± 17.7 (116) 101 ± 19 (25) 96.3 ± 16.9 () Serum cholesterol (mg/dL) 189.3 ± 36.5 (120) 179.1 ± 35.7 (42) 194.8 ± 36.0 (78) 190.4 ± 33.3 (68) 181.4 ± 36.7 (25) 195.6 ± 30.4 (43) LDL cholesterol (mg/dL) 106 ± 31.4 (109) 101.1 ± 30.4 (36) 107.6 ± 31.9 (73) 106.1 ± 27.6 (62) 100.6 ± 31.7 (21) 108.9 ± 25.2 (41) HDL cholesterol (mg/dL) 59.8 ± 19.4 (120) 50.5 ± 13.8 (42) 64.9 ± 20.1 (78) 61.2 ± 19.7 (68) 53.1 ± 13.9 (25) 65.8 ± 21.1 (43) Triglycerides (mg/dL) 124.5 ± 71.7 (121) 147.9 ± 84.7 (42) 112 ± 60.7 (79) 117.5 ± 74.6 (68) 145.5 ± 94.4 (25) 101.3 ± 55.2 (43) Systolic blood pressure (mm Hg) 124.1 ± 17.4 (220) 128.3 ± 16.6 (71) 122 ± 17.4 (149) 123.6 ± 17.2 (131) 126.5 ± 17.5 (44) 122 ± 16.9 (87) Diastolic blood pressure (mm Hg) 74.8 ± 9.5 (220) 76.5 ± 9.9 (71) 73.9 ± 9.2 (149) 75.1 ± 9.5 (131) 76.2 ± 9.7 (44) 74.5 ± 9.4 (87) Values are expressed as mean ± SD, with n in parentheses.
HDL = high-density lipoprotein; LDL = low-density lipoprotein.
- TABLE 2
Characteristics of Subjects with Extremes of Body Mass Index in Group with Complete Gallbladder Emptying
Total Male Female Characteristic Upper 20% Lower 20% Upper 20% Lower 20% Upper 20% Lower 20% Body mass index 36.3 ± 6.0 (24) 20.1 ± 1.9* (28) 36.5 ± 8.0 (11) 20.5 ± 1.6* (6) 36.1 ± 4.2 (13) 19.9 ± 2.0* (22) Age (y) 56.5 ± 15.0 (28) 50.5 ± 15.6 (28) 54.8 ± 17.6 (11) 54.7 ± 18.7 (6) 57.5 ± 13.6 (17) 49.4 ± 14.9 (22) Male (n) 11 6 11 6 0 0 Female (n) 17 22 0 0 17 22 Weight (kg) 99.4 ± 24.5 (27) 56.6 ± 8.2* (28) 114.6 ± 27.3 (11) 63.7 ± 7.0* (6) 88.0 ± 16.0 (16) 54.6 ± 7.5* (22) Fasting glucose (mg/dL) 104.1 ± 21.1 (18) 98.8 ± 20.7 (28) 112.9 ± 30.6 (7) 100.3 ± 18.2 (6) 98.5 ± 10.4 (11) 98.4 ± 21.7 (22) Serum cholesterol (mg/dL) 181.3 ± 16.5 (11) 192.4 ± 36.7 (16) 172.3 ± 18.5 (4) 135.5 ± 0.7 (2) 186.4 ± 14.1 (7) 200.5 ± 31.4 (14) LDL cholesterol (mg/dL) 100.6 ± 20.5 (10) 104.8 ± 30.8 (15) 90.3 ± 17.9 (4) 72.0 ± 2.8 (2) 107.5 ± 20.6 (6) 109.8 ± 30.0 (13) HDL cholesterol (mg/dL) 53.4 ± 9.5 (11) 71 ± 20.5* (16) 53 ± 10 (4) 50.5 ± 7.8 (2) 53.6 ± 10.0 (7) 73.9 ± 20.1* (14) Triglycerides (mg/dL) 119.1 ± 44.7 (11) 81.1 ± 32.7* (16) 137.5 ± 59.5 (4) 66.5 ± 21.9 (2) 108.5 ± 34.8 (7) 83.1 ± 34.0* (14) Systolic blood pressure (mm Hg) 132 ± 17.6 (25) 114.2 ± 13.1* (28) 131.8 ± 19.6 (10) 115.2 ± 11.3 (6) 132.1 ± 16.8 (15) 113.9 ± 13.8* (22) Diastolic blood pressure (mm Hg) 78.7 ± 6.5 (25) 68.8 ± 8.4* (28) 77.4 ± 7.1 (10) 72.5 ± 10.2 (6) 79.6 ± 6.2 (15) 67.8 ± 7.7* (22) ↵* P ≤ 0.05, comparing values for upper and lower quintiles for each parameter.
HDL = high-density lipoprotein; LDL = low-density lipoprotein.
Values are expressed as mean ± SD, with n in parentheses.
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