Article Figures & Data
Figures
- FIGURE 1.
Coronal CT (left), PET (middle), and PET/CT (right) images of 68Ga-PSMA ligand (first 2 rows) and coronal CT (left), SPECT (middle), and SPECT/CT (right) images of 99mTc-DMSA (bottom row) in 2 different patients with normal renal profile. 99mTc-DMSA images are from 32-y-old average-sized man with microscopic hematuria and CT showing small right kidney and no parenchymal abnormalities in either kidney. Scan was performed 3 h after intravenous injection of 185 MBq (5 mCi) of 99mTc-DMSA using Discovery 670 16-slice SPECT/CT camera (GE Healthcare) equipped with high-resolution parallel-hole collimator (imaging parameters: low-dose CT; SPECT using 20 s per view, 60 views in 360° rotation, 128 × 128 matrix, no zoom, 20% window centered at 140 keV, and iterative reconstruction with 2 iterations and 10 subsets). 68Ga-PSMA ligand PET/CT images are from 59-y-old average-sized man with prostate cancer. Scan was performed 60 min after intravenous injection of 185 MBq (5 mCi) of 68Ga-PSMA ligand using Philips Gemini Time of Flight PET/CT camera (Philips Medical Systems) (imaging parameters: low-dose CT using 120 kVp and 40 mAs; PET using 3 min/bed position from skull base to mid thighs). 68Ga-PSMA ligand PET produced high-resolution images of kidneys with high uptake (SUVmax in left renal cortex, 50.7) and excellent separation of renal columns as compared with 99mTc-DMSA scanning. Clx = calyceal structures; P = pelvis (with mild pelvic activity); RC = renal cortex; R-col = renal column; RM = renal medulla.
- FIGURE 2.
Transaxial CT (top), PET (middle), and PET/CT (bottom) images of 68Ga-PSMA ligand in 67-y-old man with prostate cancer and normal renal profile. Equipment and parameters are same as for Figure 1. PET image shows cortical defects in both kidneys corresponding to low-attenuation areas/cysts (arrows) measuring 32 × 34 mm on right and 8 × 10 mm on left. SUVmax was 74.7 in right renal cortex and 67.4 in right renal column.
