Research ArticleImaging

Intra- and Interobserver Agreement of SUV SPECT Quantitative SPECT/CT Processing Software, Applied in Clinical Settings for Patients with Solid Renal Tumors

Antonios Tzortzakakis, Maria Holstensson, Eva Hagel, Mattias Karlsson and Rimma Axelsson
Journal of Nuclear Medicine Technology September 2019, 47 (3) 258-262; DOI: https://doi.org/10.2967/jnmt.118.223297

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Female patient with 15-mm solid neoplasm (arrows) on lateral aspect of left kidney. Scintigraphy coronal view (left) demonstrates absence of 99mTc-sestamibi in place of renal tumor. Directly after SPECT acquisition, CT scan (right) was performed for anatomic correlation. Middle panel is fused coronal SPECT/CT image. Renal tumor was diagnosed as clear cell carcinoma on histopathologic grounds.

  • FIGURE 2.
    FIGURE 2.

    (A) All individual SUVmax measurements in solid renal tumors for both readers. (B) All individual SUVmax measurements in ipsilateral renal parenchyma. T = renal tumor; N = healthy renal parenchyma.

  • FIGURE 3.
    FIGURE 3.

    Coronal 99mTc-sestamibi SPECT/CT fused image of bilaterally healthy kidney parenchyma, with regions of uneven uptake in left kidney and more even uptake in right kidney.

Tables

  • TABLE 1

    ICCs for SUVmean, SUVmax, and SUVpeak for Repeated Measurements by Same Reader

    Same readerSUVmeanSUVpeakSUVmax
    Reader 1: T0.984 (0.972–0.991)0.989 (0.980–0.994)0.989 (0.981–0.994)
    Reader 2: T0.954 (0.920–0.974)0.969 (0.946–0.982)0.965 (0.939–0.980)
    Reader 1: N0.975 (0.956–0.986)0.982 (0.968–0.989)0.983 (0.970–0.990)
    Reader 2: N0.932 (0.883–0.961)0.932 (0.884–0.961)0.921 (0.865–0.954)

    • T = renal tumor; N = healthy renal parenchyma.

    • Data are ICC followed by 95% confidence interval in parentheses.

  • TABLE 2

    ICCs for SUVmean, SUVmax, and SUVpeak for Repeated Measurements Between Readers

    Between readersSUVmeanSUVpeakSUVmax
    First measurement - T0.890 (0.814–0.936)0.887 (0.809–0.934)0.866 (0.775–0.922)
    First measurement - N0.732 (0.530–0.848)0.705 (0.526–0.823)0.715 (0.518–0.835)
    Second measurement - T0.858 (0.762–0.917)0.915 (0.856–0.951)0.890 (0.812–0.936)
    Second measurement - N0.734 (0.560–0.843)0.656 (0.447–0.794)0.729 (0.524–0.847)

    • T = renal tumor; N = healthy renal parenchyma.

    • Data are ICC followed by 95% confidence interval in parentheses.

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