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Journal of Nuclear Medicine Technology

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Research ArticleImaging

Findings for Differentiated Thyroid Carcinoma by γ-Camera–Based and Uptake-Probe–Based Methods in Comparison with Diagnostic Radioiodine Scanning

Biju Menon, Atanu Bhattacharjee and Sandip Basu
Journal of Nuclear Medicine Technology September 2019, 47 (3) 238-242; DOI: https://doi.org/10.2967/jnmt.118.207837
Biju Menon
1Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Mumbai, India
2Homi Bhabha National Institute, Mumbai, India; and
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Atanu Bhattacharjee
2Homi Bhabha National Institute, Mumbai, India; and
3Centre for Cancer Epidemiology, Advanced Centre for Treatment, Research, and Education in Cancer (ACTREC), Tata Memorial Centre, Mumbai, India
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Sandip Basu
1Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Mumbai, India
2Homi Bhabha National Institute, Mumbai, India; and
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  • FIGURE 1.
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    FIGURE 1.

    Neck and background count estimation by camera-based method. Bkg = background; roi = region of interest.

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    FIGURE 2.

    A 57-y-old woman who had differentiated thyroid carcinoma and skeletal metastasis (after one previous therapy). Increased stomach and salivary gland uptake is seen. Probe-based method is positive for neck uptake, but camera-based method and scan are negative.

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    FIGURE 3.

    A 67-y-old woman who had differentiated thyroid carcinoma and shoulder metastasis. Probe-based method is positive for neck uptake, whereas scan and camera-based methods are negative.

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    FIGURE 4.

    Measurements obtained through camera-based and probe-based methods are highly concordant, with Pearson correlation coefficient of 0.97.

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    FIGURE 5.

    Pairwise comparison between camera-based, probe-based, and scan findings to detect positive and negative cases.

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    TABLE 1

    κ-Test Statistics Obtained Between Performance of Camera-Based Method, Probe-Based Method, and Scan Finding (Reference) in Patients with Thyroid Carcinoma

    MethodOutcome of methodHigh/positive scan findingLow/negative scan findingκSensitivity vs. referenceSpecificity vs. reference
    Camera-basedHigh/positive11 (23.91%)6 (13.04%)0.6964.70%82.85%
    Low/negative0 (0.00%)29 (63.04%)
    Probe-based
     Cutoff, 0.1%High/positive12 (26.08%)5 (10.86%)0.4579.16%75.86%
     Low/negative7 (15.21%)22 (47.82%)
     Cutoff, 0.2%High/positive6 (13.04%)0 (0.00%)0.40100%72.5%
     Low/negative11 (23.91%)29 (63.04%)
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Journal of Nuclear Medicine Technology: 47 (3)
Journal of Nuclear Medicine Technology
Vol. 47, Issue 3
September 1, 2019
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Findings for Differentiated Thyroid Carcinoma by γ-Camera–Based and Uptake-Probe–Based Methods in Comparison with Diagnostic Radioiodine Scanning
Biju Menon, Atanu Bhattacharjee, Sandip Basu
Journal of Nuclear Medicine Technology Sep 2019, 47 (3) 238-242; DOI: 10.2967/jnmt.118.207837

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Findings for Differentiated Thyroid Carcinoma by γ-Camera–Based and Uptake-Probe–Based Methods in Comparison with Diagnostic Radioiodine Scanning
Biju Menon, Atanu Bhattacharjee, Sandip Basu
Journal of Nuclear Medicine Technology Sep 2019, 47 (3) 238-242; DOI: 10.2967/jnmt.118.207837
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Keywords

  • differentiated thyroid carcinoma
  • camera-based neck uptake
  • Thyroid uptake probe
  • radioiodine
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