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Research ArticleRadiopharmacy & Adjunctive Medications

Validation of an Ergonomic Method of Withdrawing 99mTc-Radiopharmaceuticals

Sandy Blondeel-Gomes, Solène Marie, Sabrina Loyeau, Julien Fouque, François Lokiec and Olivier Madar
Journal of Nuclear Medicine Technology March 2018, 46 (1) 49-52; DOI: https://doi.org/10.2967/jnmt.117.199133
Sandy Blondeel-Gomes
1Department of Radio-Pharmacology, Institut Curie Hospital, Paris, France; and
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Solène Marie
1Department of Radio-Pharmacology, Institut Curie Hospital, Paris, France; and
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Sabrina Loyeau
2Operational Hygiene Team, Institut Curie Hospital, Paris, France
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Julien Fouque
1Department of Radio-Pharmacology, Institut Curie Hospital, Paris, France; and
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François Lokiec
1Department of Radio-Pharmacology, Institut Curie Hospital, Paris, France; and
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Olivier Madar
1Department of Radio-Pharmacology, Institut Curie Hospital, Paris, France; and
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    FIGURE 1.

    Photo of withdrawal system: spinal needle assembled to membrane obturator IN-Stopper.

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    TABLE 1

    Activity and Volumes of Preparations

    AgentActivity (MBq)Volume (mL)
    99mTc-HMDP10,930 (10,220–11,600)5.0 (5.0–5.0)
    99mTc-HSA2,068 (1,995–2,376)3.52 (3.3–3.7)
    99mTc-albumin nanocolloid1,634 (1,368–1,814)4.78 (4.8–5.0)
    • Data are mean followed by range in parentheses.

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    TABLE 2

    Physicochemical Results for Controls

    pHRadiochemical purity (%)
    AgentConformityBaseline4 or 7 h*ConformityBaseline4 or 7 h*
    99mTc-pertechnetate eluate (n = 5)4–85.84 (5.8–6.0)5.80 (5.8–5.8)>95%99.63 (99.37–99.99)99.56 (99.34–99.99)
    99mTc-HMDP (n = 5)5–75.36 (5.0–5.5)5.36 (5.0–5.5)>95%99.63 (99.34–99.79)99.05 (98.42–99.57)
    99mTc-HSA (n = 5)2–6.55.4 (5.0–6.0)5.4 (5.0–6.0)>95%99.70 (99.05–99.99)99.51 (99.13–99.76)
    99mTc-albumin nanocolloid (n = 5)4–75.0 (5.0–5.0)5.0 (5.0–5.0)>95%99.55 (99.31–99.99)99.67 (99.10–99.99)
    • ↵* 7 h for 99mTc-pertechnetate eluate, 99mTc-HMDP, and 99mTc-HSA, and 4 h for 99mTc-albumin nanocolloid.

    • Data are mean with or without range in parentheses.

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    TABLE 3

    Activity of 99mTc-Pertechnetate Eluate Vials and Dosimetry of Dominant and Nondominant Hands

    Mean dose ± SD (μSv/MBq)
    ProcessRange of vial activity (MBq)Dominant handNondominant hand
    Routine disinfection of vial cap, reversal of vial, and drawing of syringe7,170–10,60012.3 × 10−5 ± 8.69 × 10−517.5 × 10−5 ± 9.92 × 10−5
    Insertion of spinal needle/IN-Stopper into vial10,218–11,8006.65 × 10−5 ± 3.68 × 10−50
    Disinfection of obturator cap and syringe; withdrawal of spinal needle/IN-Stopper6,790–11,2156.85 × 10−5 ± 6.81 × 10−612.1 × 10−5 ± 4.89 × 10−5
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Journal of Nuclear Medicine Technology: 46 (1)
Journal of Nuclear Medicine Technology
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March 1, 2018
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Validation of an Ergonomic Method of Withdrawing 99mTc-Radiopharmaceuticals
Sandy Blondeel-Gomes, Solène Marie, Sabrina Loyeau, Julien Fouque, François Lokiec, Olivier Madar
Journal of Nuclear Medicine Technology Mar 2018, 46 (1) 49-52; DOI: 10.2967/jnmt.117.199133

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Validation of an Ergonomic Method of Withdrawing 99mTc-Radiopharmaceuticals
Sandy Blondeel-Gomes, Solène Marie, Sabrina Loyeau, Julien Fouque, François Lokiec, Olivier Madar
Journal of Nuclear Medicine Technology Mar 2018, 46 (1) 49-52; DOI: 10.2967/jnmt.117.199133
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