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Research ArticleImaging

Pediatric Brown Adipose Tissue on 18F-FDG PET: Diazepam Intervention

Justine Cousins, Michael Czachowski, Ashok Muthukrishnan and Geoff Currie
Journal of Nuclear Medicine Technology June 2017, 45 (2) 82-86; DOI: https://doi.org/10.2967/jnmt.116.187385
Justine Cousins
1Community College of Allegheny County, Pittsburgh, Pennsylvania
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Michael Czachowski
2Department of Nuclear Medicine and Molecular Imaging, Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania
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Ashok Muthukrishnan
2Department of Nuclear Medicine and Molecular Imaging, Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania
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Geoff Currie
3Faculty of Science, Charles Sturt University, Wagga Wagga, Australia; and
4Faculty of Health Sciences, Regis University, Boston, Massachusetts
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  • FIGURE 1.
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    FIGURE 1.

    (A) Baseline 18F-FDG PET study with warmed blankets and increased room temperature demonstrated marked BAT uptake. (B) Postchemotherapy follow-up 18F-FDG PET study in same patient with warmed blankets, increased room temperature, and 10 mg of diazepam demonstrated elimination of BAT uptake.

  • FIGURE 2.
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    FIGURE 2.

    (A) Baseline 18F-FDG PET study with warmed blankets showed marked uptake in the neck, supraclavicular, mediastinal, and paravertebral regions suggestive of extensive BAT uptake. (B) Three-month study with warmed blankets showed no change from baseline. (C) Six-month study with warmed blankets prospectively showed no significant change from baseline but retrospectively showed apparent increase in focal uptake in right upper chest. (D) Nine-month study with warmed blankets and diazepam showed suppression of BAT uptake and clear demarcation of focal disease in upper right chest.

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    FIGURE 3.

    A 28-y-old man with desmoplastic small-round-cell tumor presented in October 2009 for initial 18F-FDG PET study (left) and subsequently in January 2010 (right). Both studies used approximately 270 MBq of 18F-FDG and were obtained after 60-min uptake phase. Initial image was obtained without warming techniques. Follow-up image was obtained with warming intervention. Apart from disease progression, presence and absence of significant BAT accumulation is noted. (Reprinted with permission of (1).)

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    TABLE 1

    Demographic Comparison of Groups

    ParameterWarming onlyWarming plus diazepamP
    Mean age (y)15.615.50.880
    Sex0.760
     Males57.7%50.3%
     Females42.3%39.7%
    Season0.286
     Winter19.7%33.8%
     Summer32.4%25.0%
    Mean 18F-FDG dose0.886
     MBq336.7333.0
     mCi9.19.0
    Presence of BAT uptake33.8%16.2%0.017
     Males39.0%22.0%0.093
     Females26.7%7.4%0.048
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Journal of Nuclear Medicine Technology: 45 (2)
Journal of Nuclear Medicine Technology
Vol. 45, Issue 2
June 1, 2017
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Pediatric Brown Adipose Tissue on 18F-FDG PET: Diazepam Intervention
Justine Cousins, Michael Czachowski, Ashok Muthukrishnan, Geoff Currie
Journal of Nuclear Medicine Technology Jun 2017, 45 (2) 82-86; DOI: 10.2967/jnmt.116.187385

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Pediatric Brown Adipose Tissue on 18F-FDG PET: Diazepam Intervention
Justine Cousins, Michael Czachowski, Ashok Muthukrishnan, Geoff Currie
Journal of Nuclear Medicine Technology Jun 2017, 45 (2) 82-86; DOI: 10.2967/jnmt.116.187385
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Keywords

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