RT Journal Article SR Electronic T1 Pediatric Brown Adipose Tissue on 18F-FDG PET: Diazepam Intervention JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 82 OP 86 DO 10.2967/jnmt.116.187385 VO 45 IS 2 A1 Justine Cousins A1 Michael Czachowski A1 Ashok Muthukrishnan A1 Geoff Currie YR 2017 UL http://tech.snmjournals.org/content/45/2/82.abstract AB Brown adipose tissue (BAT) has been widely reported to affect the efficacy of 18F-FDG PET in oncology. Several small studies have found that warming the patient both before 18F-FDG injection and during the uptake phase can reduce the frequency of BAT uptake. Pharmaceutical approaches such as propranolol and diazepam have also been used. Methods: We describe two case studies that demonstrated the impact of combined patient warming and diazepam administration on BAT uptake in pediatric 18F-FDG PET images. To support these findings, we performed a retrospective analysis of 139 patients: 71 who received warming only and 68 who received warming combined with diazepam. Results: BAT uptake was significantly less frequent in patients who received diazepam (16.2%) than in those who did not (33.8%) (P = 0.0167), particularly in female patients (7.4% vs. 26.7%) (P = 0.0486). Conclusion: Although patient warming alone reduces the frequency of BAT uptake, the addition of diazepam to patient warming significantly furthers the reduction in young patients, particularly female patients.