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Research ArticleRADIOPHARMACY

Fully Automated Production of Diverse 18F-Labeled PET Tracers on the ELIXYS Multireactor Radiosynthesizer Without Hardware Modification

Mark Lazari, Jeffrey Collins, Bin Shen, Mohammed Farhoud, Daniel Yeh, Brandon Maraglia, Frederick T. Chin, David A. Nathanson, Melissa Moore and R. Michael van Dam
Journal of Nuclear Medicine Technology September 2014, 42 (3) 203-210; DOI: https://doi.org/10.2967/jnmt.114.140392
Mark Lazari
1Department of Bioengineering, Henry Samueli School of Engineering, UCLA, Los Angeles, California
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
3Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California
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Jeffrey Collins
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
3Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California
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Bin Shen
4Molecular Imaging Program at Stanford (MIPS) Department of Radiology, Stanford University, Stanford, California
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Mohammed Farhoud
5Sofie Biosciences, Inc., Culver City, California; and
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Daniel Yeh
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
6Ahmanson Translational Imaging Division, David Geffen School of Medicine, UCLA, Los Angeles, California
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Brandon Maraglia
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
3Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California
5Sofie Biosciences, Inc., Culver City, California; and
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Frederick T. Chin
4Molecular Imaging Program at Stanford (MIPS) Department of Radiology, Stanford University, Stanford, California
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David A. Nathanson
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
6Ahmanson Translational Imaging Division, David Geffen School of Medicine, UCLA, Los Angeles, California
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Melissa Moore
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
3Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California
5Sofie Biosciences, Inc., Culver City, California; and
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R. Michael van Dam
1Department of Bioengineering, Henry Samueli School of Engineering, UCLA, Los Angeles, California
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
3Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California
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Article Information

vol. 42 no. 3 203-210
DOI 
https://doi.org/10.2967/jnmt.114.140392
PubMed 
25033883

Published By 
Society of Nuclear Medicine
Print ISSN 
0091-4916
Online ISSN 
1535-5675
History 
  • Received for publication March 25, 2014
  • Accepted for publication May 12, 2014
  • Published online September 4, 2014.

Article Versions

  • previous version (July 17, 2014 - 05:19).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Mark Lazari1–3,
  2. Jeffrey Collins2,3,
  3. Bin Shen4,
  4. Mohammed Farhoud5,
  5. Daniel Yeh2,6,
  6. Brandon Maraglia2,3,5,
  7. Frederick T. Chin4,
  8. David A. Nathanson2,6,
  9. Melissa Moore2,3,5 and
  10. R. Michael van Dam1–3
  1. 1Department of Bioengineering, Henry Samueli School of Engineering, UCLA, Los Angeles, California
  2. 2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
  3. 3Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California
  4. 4Molecular Imaging Program at Stanford (MIPS) Department of Radiology, Stanford University, Stanford, California
  5. 5Sofie Biosciences, Inc., Culver City, California; and
  6. 6Ahmanson Translational Imaging Division, David Geffen School of Medicine, UCLA, Los Angeles, California
  1. For correspondence or reprints contact: R. Michael van Dam, 4323 CNSI, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095. E-mail: mvandam@mednet.ucla.edu
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Journal of Nuclear Medicine Technology: 42 (3)
Journal of Nuclear Medicine Technology
Vol. 42, Issue 3
September 1, 2014
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Fully Automated Production of Diverse 18F-Labeled PET Tracers on the ELIXYS Multireactor Radiosynthesizer Without Hardware Modification
Mark Lazari, Jeffrey Collins, Bin Shen, Mohammed Farhoud, Daniel Yeh, Brandon Maraglia, Frederick T. Chin, David A. Nathanson, Melissa Moore, R. Michael van Dam
Journal of Nuclear Medicine Technology Sep 2014, 42 (3) 203-210; DOI: 10.2967/jnmt.114.140392
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  • Production of diverse PET probes with limited resources: 24 18F-labeled compounds prepared with a single radiosynthesizer
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Keywords

  • automated radiosynthesis
  • radiochemistry kits
  • 18F-FAC
  • 18F-FEAU
  • 18F-FMAU
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Fully Automated Production of Diverse 18F-Labeled PET Tracers on the ELIXYS Multireactor Radiosynthesizer Without Hardware Modification
Mark Lazari, Jeffrey Collins, Bin Shen, Mohammed Farhoud, Daniel Yeh, Brandon Maraglia, Frederick T. Chin, David A. Nathanson, Melissa Moore, R. Michael van Dam
Journal of Nuclear Medicine Technology Sep 2014, 42 (3) 203-210; DOI: 10.2967/jnmt.114.140392

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