Research ArticleIMAGING

A Portable Test System for Determination of Bacterial Endotoxins in 18F-FDG, 99mTc, and Lyophilized Reagents for Labeling with 99mTc

Neuza T.O. Fukumori, Domingos G. de Campos, Adriana V.F. Massicano, Nilda P.S. de Pereira, Constancia P.G. da Silva and Margareth M.N. Matsuda
Journal of Nuclear Medicine Technology June 2011, 39 (2) 121-124; DOI: https://doi.org/10.2967/jnmt.110.081380

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    (A) Endosafe cartridge scheme with 2 channels for sample negative control and 2 channels for sample positive control. (B) Sample channel zoom: 1 = sample negative control (sample + LAL + substrate) and 2 = sample positive control (sample + LAL + endotoxin + substrate).

  • FIGURE 2.
    FIGURE 2.

    Influence of dilution in percentage recovery of product positive control in 3 batches of 18F-FDG (A) and 99mTc (B) from undiluted to diluted samples. RPPC = recovery of product positive control.

  • FIGURE 3.
    FIGURE 3.

    Influence of dilution in percentage recovery of product positive control in 3 batches of MDP (A) and pyrophosphate (B) from undiluted to diluted samples. RPPC = recovery of product positive control.

Tables

  • TABLE 1

    Acceptability Criteria for Kinetic Chromogenic Method (6)

    ParameterAcceptability criterion
    Coefficient correlation of archived standard curve≤−0.980
    Recovery of product positive control50%–200%
    Coefficient of variation<25%
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