Article Figures & Data
Figures
- FIGURE 1.
Procedure used to investigate acquisition mode and scan time in head and neck cancer patients. Protocol allowed standard WB scanning to be performed, followed by optimized SFOV scans, without extra radiation burden to subject.
- FIGURE 2.
Normalized SUVmax versus OSEM (iteration × subset) acquired with hot sphere–to–background ratio of 4:1, showing convergence of 2D and 3D acquisition modes. ⋄ = 2D 4 min; ○ = 2D 3 min; ▵ = 2D 2 min; □ = 3D 4 min; × = 3D 3 min; + = 3D 2 min.
- FIGURE 3.
Plot of noise matching in paired 2D and 3D acquisitions with different scan times. Difference in noise means between 4-min 2D acquisition and 4-min 3D acquisition was 0.02 and not significant (P = 0.97). This was the case for 3-min (P = 0.17) and, likewise, 2-min acquisitions (P = 0.25), showing close match in noise between paired scans.
- FIGURE 4.
Plot of lesion SUVmean recorded for 2D and 3D acquisitions with different scan times. Difference in mean SUVmean between 4-min 2D acquisition and 4-min 3D acquisition was 0.14 and not significant (P = 0.54). This was the case for 3-min (P = 0.55) and, likewise, 2-min acquisitions (P = 0.45), showing no great superiority of either mode with any scan times.
- FIGURE 5.
Plot of lesion SUVmax recorded for 2D and 3D acquisitions with different scan times. Difference in uptake means between 4-min 2D acquisition and 4-min 3D acquisition was 1.43 and significant (P = 0.01). However, nonsignificant results were obtained for 3-min (P = 0.17) and, likewise, 2-min acquisitions (P = 0.57).
- FIGURE 6.
Example of noise-matched images from patient. Images depicted are from 2D 4-min (A), 3D 4-min (B), 2D 3-min (C), 3D 3-min (D), 2D 2-min (E), and 3D 2-min (F) scans. Arrow indicates lesion, and ROIs were used to define lesion SUVmax or SUVmean (solid circle in E) and uniform background area (dotted circle in E) for semiquantitative analysis.
Tables
Paired scan Mean noise (%) SD Difference P 4 min 0.02 0.97 2D 38.41 9.65 3D 38.39 8.67 3 min 0.51 0.17 3D 39.81 8.18 2D 40.32 7.67 2 min 0.67 0.25 2D 44.65 10.21 3D 45.32 9.33 No significant difference was seen in mean noise between 2D and 3D paired scans of 4, 3, and 2 min, showing that good noise-matched imaging was achieved.
Paired scan Mean SUVmean SD Difference P 4 min 0.14 0.54 2D 4.55 2.28 3D 4.69 2.6 3 min 0.11 0.55 3D 4.66 2.93 2D 4.77 2.94 2 min 0.09 0.45 2D 4.79 2.84 3D 4.7 2.67 No significant difference was seen in mean SUVmean between 2D and 3D paired scans of 4, 3, and 2 min, suggesting no great superiority of either paired acquisition mode with scan duration.
Paired scan Mean SUVmax SD Difference P 4 min 1.43 0.01 2D 13.89 8.35 3D 12.46 7.31 3 min 1.37 0.17 3D 13.10 7.49 2D 14.47 8.86 2 min 0.2 0.57 2D 13.64 7.5 3D 13.44 7.52 Significant difference was seen only in mean SUVmax for 2D and 3D paired scans of 4 min, suggesting some superiority for 2D scans.
Patient no. 2D 2 min vs. 2D 4 min 2D 2 min vs. 2D 3 min 2D 3 min vs. 2D 4 min 3D 2 min vs. 3D 4 min 3D 2 min vs. 3D 3 min 3D 3 min vs. 3D 4 min 2D 2 min vs. 3D 2 min 2D 3 min vs. 3D 3 min 2D 4 min vs. 3D 4 min 1 −1 0 −1 +2 +1 +1 0 +1 +2 2 −1 0 +1 −1 0 −1 −1 +2 −1 3 0 0 0 −1 0 +1 0 +2 +1 4 +1 +1 −1 +1 +1 0 +2 +2 +1 5 −1 0 0 +2 −1 0 +1 +2 +2 6 −1 −1 0 +1 −1 −1 +1 +1 +1 7 +2 +1 0 −2 +1 −1 −1 +2 +1 8 +1 −1 −1 −1 −1 +1 +1 +1 +1 9 −2 −1 0 0 0 0 0 +2 +2 10 +2 +2 +1 +2 +1 +1 −2 +1 +2 11 0 +1 −1 −1 0 0 +1 +1 +2 12 0 −2 +1 0 0 +1 −1 +1 +1 13 +2 +1 +2 +1 +1 +1 0 +1 +1 14 0 0 0 0 0 0 0 0 0 Mean 0.14 0.07 0.07 0.21 0.14 0.21 0.07 1.36 1.14 SE 0.35 0.29 0.25 0.35 0.21 0.21 0.29 0.17 0.23 95% CI −0.60 to −0.89 −0.55 to −0.69 −0.46 to −0.60 −0.54 to −0.97 −0.30 to −0.59 −0.25 to −0.68 −0.55 to −0.69 0.99 to −1.72 0.64 to −1.64 P 0.34 0.4 0.39 0.28 0.25 0.17 0.4 0.0001 0.0001 Scan choice Non Non Non Non Non Non Non 3D 3D Non = No significant preference between scans was observed.
Score of 0 suggested no preference; score of +1 implied second scan was superior, whereas −1 signified that first scan was superior. Similarly, score of ±2 indicated one scan, compared with other, was far superior.
P Scan Age at scan (y) Weight (kg) Height (m) BMI (kgm−2) Blood glucose (mmol−1) 2D 4 min 0.82 0.97 0.18 0.12 0.45 3 min 0.66 0.73 0.28 0.06 0.43 2 min 0.57 0.93 0.43 0.30 0.53 3D 4 min 0.65 0.75 0.45 0.15 0.47 3 min 0.69 0.83 0.50 0.26 0.43 2 min 0.67 0.67 0.59 0.17 0.33 No significant correlations were observed between any 2D or 3D acquisition modes and scan duration with age, weight, height, BMI, or blood glucose.
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