PT  - JOURNAL ARTICLE
AU  - Bal Sanghera
AU  - Gerry Lowe
AU  - David Wellstead
AU  - John Lowe
AU  - Jane Chambers
AU  - WaiLup Wong
TI  - Scan-Time Reduction Using Noise-Matched Images in 2- and 3-Dimensional Bismuth Germanate PET/CT: Clinical Study in Head and Neck Cancer
AID  - 10.2967/jnmt.108.055855
DP  - 2009 Jun 01
TA  - Journal of Nuclear Medicine Technology
PG  - 74--82
VI  - 37
IP  - 2
4099  - http://tech.snmjournals.org/content/37/2/74.short
4100  - http://tech.snmjournals.org/content/37/2/74.full
SO  - J. Nucl. Med. Technol.2009 Jun 01; 37
AB  - We quantitatively and qualitatively investigated 2-dimensional (2D) and 3-dimensional (3D) imaging with scan-time reduction in 14 patients with 17 lesions, who had known or suspected head and neck cancer, using a bismuth germanate (BGO) crystal based PET/CT scanner with noise-matched images. Methods: A 2D and 3D acquisition protocol using scan-time reduction on an axial single field of view resulted in a 2D 4-, 3D 4-, 3D 3-, 2D 3-, 2D 2-, and 3D 2-min scan sequence to minimize redistribution and decay bias. Tumor maximum standardized uptake values (SUVmax) and tumor mean standardized uptake values (SUVmean) were recorded, and two observers in consensus investigated lesion conspicuity between 2D and 3D paired 4-, 3-, and 2-min noise-matched images. Results: We found some minor advantages quantitatively in favor of 2D scanning, with higher mean SUVmax, and qualitatively in favor of 3D scanning, with lesion conspicuity preference. In our cohort, no great advantage or disadvantage to using either acquisition mode was observed, and all lesions were seen irrespective of acquisition mode and scan time. Conclusion: In head and neck cancer patients, we can recommend a scan-time reduction from 4 to 3 min/bed position in 2D acquisitions with a BGO-based PET/CT scanner, using our imaging protocol and reconstruction defaults.