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OtherIMAGING

Rest Versus Stress Ejection Fraction on Gated Myocardial Perfusion SPECT

Janelle M. Wheat and Geoffrey M. Currie
Journal of Nuclear Medicine Technology December 2005, 33 (4) 218-223;
Janelle M. Wheat
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Geoffrey M. Currie
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  • FIGURE 1.
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    FIGURE 1.

    Bivariate fit of rest EF and stress EF for matched pairs.

  • FIGURE 2.
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    FIGURE 2.

    Bland–Altman analysis of mean of stress/rest matched pairs vs. ΔEF shows no trend toward under- or overestimation of stress EF. Mean stress EF was 56.3%, mean rest EF was 56.9%, and mean difference in EF indicated by solid horizontal line was −0.65%. Outer dashed lines represent 95% limits of agreement, whereas inner dotted lines represent 95% CI of EF difference.

  • FIGURE 3.
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    FIGURE 3.

    Bivariate fit of transient dilatation and ΔEF demonstrates weak negative correlation suggesting negative ΔEF may be associated with prolonged poststress transient dilatation.

  • FIGURE 4.
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    FIGURE 4.

    One-way ANOVA of transient dilatation by stress method demonstrating, despite small overlap of 95% CIs (diamonds), a statistically significant difference between mean transient dilatation for exercise stress and combined exercise/persantin compared with persantin stress (P = 0.02).

  • FIGURE 5.
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    FIGURE 5.

    One-way ANOVA of transient dilatation by scintigraphic findings demonstrating overlap of 95% CIs (diamonds) and no statistically significant difference between mean transient dilatation across scintigraphic findings (P = 0.07) despite the higher mean score of the reversible category.

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    TABLE 1

    Summary of Functional Data for Stress and Rest Studies

    ParameterEF (%)EDV (mL)ESV (mL)
    Stress mean56.3 (54.3–58.3)99.5 (93.2–105.9)46.5 (41.8–51.2)
    Rest mean56.9 (55.0–58.9)100.2 (93.9–106.6)46.2 (41.5–50.8)
    Stress/rest matched pairs (P)0.150.530.69
    • Values in parentheses represent 95% CI. Overlap of stress/rest 95% CIs supports lack of statistically significant difference indicated by the matched pairs P value.

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    TABLE 2

    Statistical Significance and Relative Risk Calculated for Independent Predictors of a Negative ΔEF

    Independent predictors of negative ΔEFMean ΔEF (%)P value vs. mean of 0Relative risk
    Stress to scan time < 45 min−0.960.041.2
    Transient dilatation (>1)−1.60.011.3
    Rest EDV 70–100 mL−2.10.0071.1
    Rest ESV 25–50 mL−1.60.031.5
    Rest EF > 70%−2.70.041.2
    Stress EF < 50%−2.60.0031.4
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Journal of Nuclear Medicine Technology: 33 (4)
Journal of Nuclear Medicine Technology
Vol. 33, Issue 4
December 1, 2005
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Rest Versus Stress Ejection Fraction on Gated Myocardial Perfusion SPECT
Janelle M. Wheat, Geoffrey M. Currie
Journal of Nuclear Medicine Technology Dec 2005, 33 (4) 218-223;
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Rest Versus Stress Ejection Fraction on Gated Myocardial Perfusion SPECT
Janelle M. Wheat, Geoffrey M. Currie
Journal of Nuclear Medicine Technology Dec 2005, 33 (4) 218-223;

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