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OtherIMAGING

The Effect of Selected Preparation Variables on the Radiochemical Purity of 99mTc-Sestamibi

Jeffrey P. Norenberg, Madhur P. Vaidya, William B. Hladik, Dorothy R. Pathak, Jerry L. Born, Tamara L. Anderson and Timothy R. Carroll
Journal of Nuclear Medicine Technology March 2005, 33 (1) 34-41;
Jeffrey P. Norenberg
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Madhur P. Vaidya
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William B. Hladik III
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Dorothy R. Pathak
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Jerry L. Born
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Tamara L. Anderson
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Timothy R. Carroll
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  • Article
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Article Figures & Data

Tables

    • View popup
    TABLE 1

    Twenty-Experiment Run Design

    Run no.Generator ingrowth time (h)Eluate age (h)Generator manufacturerActivity (MBq)
    1240DuPont5,550
    2240DuPont37,000
    3243DuPont21,275
    4486DuPont21,275
    5720DuPont5,550
    6720DuPont37,000
    7726DuPont5,550
    8726DuPont21,275
    9240Mallinckrodt21,275
    10246Mallinckrodt5,550
    11246Mallinckrodt37,000
    12483Mallinckrodt37,000
    13720Mallinckrodt5,550
    14720Mallinckrodt37,000
    15726Mallinckrodt21,275
    16240Medi-Physics5,550
    17240Medi-Physics37,000
    18246Medi-Physics5,550
    19720Medi-Physics5,550
    20726Medi-Physics37,000
    • View popup
    TABLE 2

    Baker-Flex TLC RCP at 0 Hours

    Run no.Kit preparation 1Kit preparation 2Mean RCP
    Sample 1Sample 2Sample 3Sample 1Sample 2Sample 3
    196.0496.9296.3795.9795.3496.1196.13
    292.3592.9392.6193.4493.8794.0393.21
    396.5495.8895.9392.9293.4493.5994.72
    497.0197.3096.5893.7394.1494.2295.50
    596.5496.0196.3397.1097.5997.2396.80
    692.1391.8991.8594.1694.0594.1993.05
    795.9896.1796.2396.6596.1195.8396.16
    894.8194.6694.9594.0994.3794.3294.53
    992.4792.3092.3293.2593.2093.7692.88
    1097.6297.0897.7797.1196.9897.8197.40
    1192.4192.8692.8393.4493.5393.2193.05
    1293.7994.0394.3393.0493.1393.2793.60
    1395.1595.8895.6096.8697.1897.1196.30
    1495.0395.7995.3493.9794.1494.0594.72
    1596.4996.6996.1197.3297.4997.6796.96
    1696.1896.3095.9396.0296.1596.3796.16
    1795.9195.9596.1896.7296.5696.8196.36
    1897.4996.8196.9397.5497.4897.1297.23
    1997.1297.2297.4196.8996.2696.2296.85
    2096.1696.2796.0596.2396.0396.2596.17
    • Kit preparation 1 and kit preparation 2 contain, respectively, results of 2 data collection periods.

    • View popup
    TABLE 3

    Baker-Flex TLC RCP at 6 Hours

    Run no.Kit preparation 1Kit preparation 2Mean RCP
    Sample 1Sample 2Sample 3Sample 1Sample 2Sample 3
    195.7495.4596.0296.6995.9896.0795.99
    294.1194.2694.1592.4292.3992.0493.23
    393.8593.7093.6195.5796.0196.3194.84
    493.8994.0493.7697.2297.1396.8995.49
    597.3297.5797.2396.0196.1295.9996.71
    693.9394.1494.1091.1592.7892.1593.04
    796.1796.4996.5796.0395.8995.5496.12
    894.6494.7894.5994.1993.8793.8294.32
    993.3493.3093.6193.2993.0692.8493.24
    1097.5597.5197.8097.3297.4197.3397.49
    1194.0293.8893.9092.8993.9193.1493.62
    1293.4593.1793.1094.1293.9893.5593.56
    1396.8797.0397.1295.7394.9494.7996.08
    1494.9895.0895.1096.0796.6696.1395.67
    1597.8397.9697.8896.5296.6896.4397.22
    1696.2896.2596.6195.7696.2996.2296.24
    1797.0297.1797.2395.8296.0895.3696.45
    1897.3597.1497.4396.1296.5496.3396.82
    1997.0197.0596.9896.8797.1197.1497.03
    2096.1696.0796.1096.1396.8296.3296.27
    • Kit preparation 1 and kit preparation 2 contain, respectively, results of 2 data collection periods.

    • View popup
    TABLE 4

    HPLC RCP at 0 and 6 Hours

    Run No.0 h6 h
    Kit preparation 1Kit preparation 2Mean RCPKit preparation 1Kit preparation 2Mean RCP
    195.8795.4395.6596.5496.4096.47
    292.0193.7892.8991.3793.6692.51
    396.4493.1794.8195.6393.7994.71
    496.6193.7395.1796.4093.3594.88
    596.4497.1596.7996.5197.6297.06
    689.9593.9391.9492.0993.7892.94
    795.9594.0394.9995.2397.0496.13
    894.9394.6694.7994.0195.1994.60
    992.5493.1192.8292.2693.3192.79
    1097.4097.2297.3197.6596.0896.87
    1192.8893.4193.1592.9092.1092.50
    1293.9793.6893.8293.4993.0293.25
    1395.8596.6496.2495.8597.5196.68
    1495.9794.1095.0396.4794.1095.29
    1596.0497.3896.7196.8197.2397.02
    1695.9695.6395.8096.9195.5696.24
    1796.0096.5896.2995.2196.9596.08
    1897.3897.3897.3896.3897.4196.89
    1996.9796.1196.5496.8197.3297.07
    2095.8095.9195.8596.6195.8096.21
    • Kit preparation 1 and kit preparation 2 contain, respectively, results of 2 data collection periods.

    • View popup
    TABLE 5

    Predicted RCP Values for All 81 Experiments Using Equation with Coefficients for Baker-Flex TLC and HPLC Methods

    Run no.Generator ingrowth time (h)Eluate age (h)Generator manufacturerActivity (MBq)Baker-Flex TLC RCPHPLC RCP
    1240DuPont5,55096.1596.14
    2480DuPont5,55096.2396.27
    3720DuPont5,55096.3196.40
    4243DuPont5,55096.9296.69
    5483DuPont5,55096.7096.43
    6723DuPont5,55096.4996.17
    7246DuPont5,55097.6997.25
    8486DuPont5,55097.1896.60
    9726DuPont5,55096.6695.95
    10240DuPont21,27594.6694.34
    11480DuPont21,27594.7494.88
    12720DuPont21,27594.8295.41
    13243DuPont21,27595.0596.99
    14483DuPont21,27594.8395.04
    15723DuPont21,27594.6295.19
    16246DuPont21,27595.4395.44
    17486DuPont21,27594.9295.20
    18726DuPont21,27594.4194.96
    19240DuPont37,00093.1892.54
    20480DuPont37,00093.2693.48
    21720DuPont37,00093.3494.43
    22243DuPont37,00093.1893.09
    23483DuPont37,00092.9693.65
    24723DuPont37,00092.7594.20
    25246DuPont37,00093.1893.64
    26486DuPont37,00092.6793.81
    27726DuPont37,00092.1693.98
    28240Mallinckrodt5,55093.8894.43
    29480Mallinckrodt5,55095.2695.71
    30720Mallinckrodt5,55096.6496.98
    31243Mallinckrodt5,55095.5095.62
    32483Mallinckrodt5,55096.5896.51
    33723Mallinckrodt5,55097.6797.40
    34246Mallinckrodt5,55097.1196.82
    35486Mallinckrodt5,55097.9197.32
    36726Mallinckrodt5,55098.6997.82
    37240Mallinckrodt21,27592.9192.71
    38480Mallinckrodt21,27594.2894.40
    39720Mallinckrodt21,27595.6696.08
    40243Mallinckrodt21,27594.1493.90
    41483Mallinckrodt21,27595.2295.20
    42723Mallinckrodt21,27596.3196.50
    43246Mallinckrodt21,27595.3895.10
    44486Mallinckrodt21,27596.1696.01
    45726Mallinckrodt21,27596.9596.92
    46240Mallinckrodt37,00091.9390.99
    47480Mallinckrodt37,00093.3093.09
    48720Mallinckrodt37,00094.6895.18
    49243Mallinckrodt37,00092.7892.19
    50483Mallinckrodt37,00093.8693.89
    51723Mallinckrodt37,00094.9595.60
    52246Mallinckrodt37,00093.6393.39
    53486Mallinckrodt37,00094.4294.70
    54726Mallinckrodt37,00095.2196.02
    55240Medi-Physics5,55095.9696.51
    56480Medi-Physics5,55096.5196.56
    57720Medi-Physics5,55097.0796.62
    58243Medi-Physics5,55096.5696.71
    59483Medi-Physics5,55096.8296.38
    60723Medi-Physics5,55097.0896.05
    61246Medi-Physics5,55097.1696.92
    62486Medi-Physics5,55097.1296.20
    63726Medi-Physics5,55097.0995.48
    64240Medi-Physics21,27596.2596.28
    65480Medi-Physics21,27596.8196.74
    66720Medi-Physics21,27597.3797.21
    67243Medi-Physics21,27596.4796.48
    68483Medi-Physics21,27596.7396.56
    69723Medi-Physics21,27597.0096.64
    70246Medi-Physics21,27596.6996.69
    71486Medi-Physics21,27596.6696.38
    72726Medi-Physics21,27596.6396.07
    73240Medi-Physics37,00096.5596.67
    74480Medi-Physics37,00097.1196.05
    75720Medi-Physics37,00097.6796.92
    76243Medi-Physics37,00096.3997.79
    77483Medi-Physics37,00096.6596.25
    78723Medi-Physics37,00096.9196.74
    79246Medi-Physics37,00096.2297.22
    80486Medi-Physics37,00096.1996.46
    81726Medi-Physics37,00096.1696.56
    • View popup
    TABLE 6

    Observed and Predicted Values of RCP for 20-Experiment Run

    Run no.Generator ingrowth time (h)Eluate age (h)Generator manufacturerActivity (MBq)RCP HPLC obsRCP HPLC predRCP ITLC obsRCP ITLC pred
    1240DuPont5,55096.0696.1495.7696.15
    2240DuPont37,00092.7092.5494.0293.18
    3243DuPont21,27594.7694.8993.5795.05
    4486DuPont21,27595.0295.2093.9894.92
    5720DuPont5,55096.9396.4097.3696.32
    6720DuPont37,00092.4494.4394.0993.34
    7726DuPont5,55095.5695.9596.2796.66
    8726DuPont21,27594.7094.9694.5094.41
    9240Mallinckrodt21,27592.8092.7193.4292.90
    10246Mallinckrodt5,55097.0996.8297.4997.12
    11246Mallinckrodt37,00092.8293.3993.6893.63
    12483Mallinckrodt37,00093.5493.8993.2193.86
    13720Mallinckrodt5,55096.4696.9897.0496.64
    14720Mallinckrodt37,00095.1695.1894.6094.68
    15726Mallinckrodt21,27596.8796.9297.7296.95
    16240Medi-Physics5,55096.0296.5196.3095.96
    17240Medi-Physics37,00096.1896.0596.9396.55
    18246Medi-Physics5,55097.1496.9297.3397.16
    19720Medi-Physics5,55096.8096.6296.7297.07
    20726Medi-Physics37,00096.0396.6596.1396.16
    • obs = observed; pred = predicted.

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Journal of Nuclear Medicine Technology: 33 (1)
Journal of Nuclear Medicine Technology
Vol. 33, Issue 1
March 1, 2005
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The Effect of Selected Preparation Variables on the Radiochemical Purity of 99mTc-Sestamibi
Jeffrey P. Norenberg, Madhur P. Vaidya, William B. Hladik, Dorothy R. Pathak, Jerry L. Born, Tamara L. Anderson, Timothy R. Carroll
Journal of Nuclear Medicine Technology Mar 2005, 33 (1) 34-41;

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The Effect of Selected Preparation Variables on the Radiochemical Purity of 99mTc-Sestamibi
Jeffrey P. Norenberg, Madhur P. Vaidya, William B. Hladik, Dorothy R. Pathak, Jerry L. Born, Tamara L. Anderson, Timothy R. Carroll
Journal of Nuclear Medicine Technology Mar 2005, 33 (1) 34-41;
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