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Journal of Nuclear Medicine Technology

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OtherIMAGING

Dual-Phase 99mTc-Sestamibi Imaging: Its Utility in Parathyroid Hyperplasia and Use of Immediate/Delayed Image Ratios to Improve Diagnosis of Hyperparathyroidism

Leonie Gordon, William Burkhalter and Eugene Mah
Journal of Nuclear Medicine Technology December 2002, 30 (4) 179-184;
Leonie Gordon
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William Burkhalter
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Eugene Mah
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  • FIGURE 1.
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    FIGURE 1.

    ROIs used for I/D ratio calculation.

  • FIGURE 2.
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    FIGURE 2.

    Dual-phase images from patient diagnosed with bilateral hyperplasia confirmed by histopathology after subtotal parathyroidectomy.

  • FIGURE 3.
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    FIGURE 3.

    Dual-phase images from patient with nuclear medicine diagnosis of left inferior adenoma that was confirmed by pathology after left inferior excision.

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    FIGURE 4.

    Typical benign dual-phase 99mTc-MIBI parathyroid images.

  • FIGURE 5.
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    FIGURE 5.

    I/D thyroid ratios for benign parathyroid, hyperplasia, and adenoma.

  • FIGURE 6.
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    FIGURE 6.

    Average I/D ratios of thyroid region for benign parathyroid, hyperplasia, and adenoma.

  • FIGURE 7.
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    FIGURE 7.

    Plot of I/D imaging time interval vs. calculated I/D thyroid ratio. Line represents line of best fit having equation y = 0.3824x + 1.916 (r2 = 0.0247).

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    TABLE 1

    Summary of Expected I/D and Right/Left Thyroid Ratios

    DiseaseI/D ratio
    Benign≫1
    Hyperplasia>1
    <Benign
    Adenoma>1
    >Hyperplasia
    <Benign
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    TABLE 2

    Average I/D Ratios for Thyroid, Left and Right Lobe Regions Grouped for Benign, Hyperplasia, and Adenoma Groups

    ThyroidI/D ratio
    Benign3.10 ± 0.77
    Hyperplasia2.26 ± 0.68
    Adenoma2.80 ± 0.95
    • Results are expressed as average ± 1 SD.

    • View popup
    TABLE 3

    Results of 2-Tailed Student t Test Performed on I/D Thyroid Ratios

    I/D ratioP
    Benign vs. hyperplasia0.020
    Benign vs. adenoma0.381
    Hyperplasia vs. adenoma0.033
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Journal of Nuclear Medicine Technology: 30 (4)
Journal of Nuclear Medicine Technology
Vol. 30, Issue 4
December 1, 2002
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Dual-Phase 99mTc-Sestamibi Imaging: Its Utility in Parathyroid Hyperplasia and Use of Immediate/Delayed Image Ratios to Improve Diagnosis of Hyperparathyroidism
Leonie Gordon, William Burkhalter, Eugene Mah
Journal of Nuclear Medicine Technology Dec 2002, 30 (4) 179-184;

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Dual-Phase 99mTc-Sestamibi Imaging: Its Utility in Parathyroid Hyperplasia and Use of Immediate/Delayed Image Ratios to Improve Diagnosis of Hyperparathyroidism
Leonie Gordon, William Burkhalter, Eugene Mah
Journal of Nuclear Medicine Technology Dec 2002, 30 (4) 179-184;
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