¹⁸F-FDG PET/CT vs. ⁶⁸Ga-PSMA-11 PET/CT in evaluation of distant metastatic disease in recurrent Renal Cell Carcinoma

Abstract

The prostate-specific membrane antigen (PSMA) expression has been observed in neo-vasculature of various malignancies. We present a case of metastatic renal cell carcinoma (RCC), with comparative FDG-PET/CT and ⁶⁸Ga-PSMA-11 imaging, in which FDG-PET/CT failed to detect metastatic thyroid disease and showed less FDG concentrating lesions in other sites, while ⁶⁸Ga-PSMA-11 PET/CT scan identified metastatic thyroid disease and demonstrated intensely PSMA expressing distant metastatic lesions. Thus ⁶⁸Ga-PSMA-11 PET/CT may be contemplated a potentially useful imaging technique to detect metastasis and also to guide choice of specific treatments like PSMA-based radionuclide therapy in patients with recurrent metastatic RCC.