RT Journal Article SR Electronic T1 18F-FDG PET/CT vs. 68Ga-PSMA-11 PET/CT in evaluation of distant metastatic disease in recurrent Renal Cell Carcinoma JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP jnmt.122.264014 DO 10.2967/jnmt.122.264014 A1 Rahul V Parghane A1 Sandip Basu YR 2022 UL http://tech.snmjournals.org/content/early/2022/08/30/jnmt.122.264014.abstract AB The prostate-specific membrane antigen (PSMA) expression has been observed in neo-vasculature of various malignancies. We present a case of metastatic renal cell carcinoma (RCC), with comparative FDG-PET/CT and 68Ga-PSMA-11 imaging, in which FDG-PET/CT failed to detect metastatic thyroid disease and showed less FDG concentrating lesions in other sites, while 68Ga-PSMA-11 PET/CT scan identified metastatic thyroid disease and demonstrated intensely PSMA expressing distant metastatic lesions. Thus 68Ga-PSMA-11 PET/CT may be contemplated a potentially useful imaging technique to detect metastasis and also to guide choice of specific treatments like PSMA-based radionuclide therapy in patients with recurrent metastatic RCC.