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Journal of Nuclear Medicine Technology

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OtherTeaching Case Studies

18F-FDG PET/CT vs. 68Ga-PSMA-11 PET/CT in evaluation of distant metastatic disease in recurrent Renal Cell Carcinoma

Rahul V Parghane and Sandip Basu
Journal of Nuclear Medicine Technology August 2022, jnmt.122.264014; DOI: https://doi.org/10.2967/jnmt.122.264014
Rahul V Parghane
1 Radiation Medicine Centre (BARC), India;
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Sandip Basu
2 RADIATION MEDICINE CENTRE (BARC); Homi Bhabha National Institute, India
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Abstract

The prostate-specific membrane antigen (PSMA) expression has been observed in neo-vasculature of various malignancies. We present a case of metastatic renal cell carcinoma (RCC), with comparative FDG-PET/CT and 68Ga-PSMA-11 imaging, in which FDG-PET/CT failed to detect metastatic thyroid disease and showed less FDG concentrating lesions in other sites, while 68Ga-PSMA-11 PET/CT scan identified metastatic thyroid disease and demonstrated intensely PSMA expressing distant metastatic lesions. Thus 68Ga-PSMA-11 PET/CT may be contemplated a potentially useful imaging technique to detect metastasis and also to guide choice of specific treatments like PSMA-based radionuclide therapy in patients with recurrent metastatic RCC.

  • Oncology: GU
  • PET/CT
  • 177Lu-PSMA-617 therapy
  • 18F-FDG PET/CT
  • 68Ga-PSMA-11 PET/CT
  • Clear cell carcinoma
  • Renal cell carcinoma

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Journal of Nuclear Medicine Technology: 50 (4)
Journal of Nuclear Medicine Technology
Vol. 50, Issue 4
December 1, 2022
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18F-FDG PET/CT vs. 68Ga-PSMA-11 PET/CT in evaluation of distant metastatic disease in recurrent Renal Cell Carcinoma
Rahul V Parghane, Sandip Basu
Journal of Nuclear Medicine Technology Aug 2022, jnmt.122.264014; DOI: 10.2967/jnmt.122.264014

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18F-FDG PET/CT vs. 68Ga-PSMA-11 PET/CT in evaluation of distant metastatic disease in recurrent Renal Cell Carcinoma
Rahul V Parghane, Sandip Basu
Journal of Nuclear Medicine Technology Aug 2022, jnmt.122.264014; DOI: 10.2967/jnmt.122.264014
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More in this TOC Section

  • Confirmation of Intracranial Neuroendocrine Metastasis Utilizing 68Ga-DOTATATE PET/CT
  • Gastrosplenic Fistula Secondary to Simultaneous Gastric and Splenic Diffuse Large B Cell Lymphoma
  • Evaluation of Hepatopulmonary Syndrome with 99mTc-Macroaggregated Albumin Scintigraphy
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Keywords

  • Oncology: GU
  • PET/CT
  • 177Lu-PSMA-617 therapy
  • 18F-FDG PET/CT
  • 68Ga-PSMA-11 PET/CT
  • Clear cell carcinoma
  • Renal cell carcinoma
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