A Better Method of Quality Control for Technetium-99m Sestamibi

Abstract

The accepted method of quality control for technetium-99m (^99mTc) sestamibi as published by the manufacturer requires the use of an aluminum oxide-coated plastic thin layer chromatography plate developed with ethanol. This procedure requires meticulous attention to chromatographic technique and requires at least 30 min to complete. We propose a separation of impurities via liquid column chromatography which uses a Sep-Pak alumina N cartridge to provide a faster and simpler method for analysis of the radiochemical purity of ^99mTc sestamibi.