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Research ArticleBrief Communication

Alternative Isotope Options for Amyloidosis Imaging: A Technologist’s Perspective

Jaime Warren
Journal of Nuclear Medicine Technology May 2023, 264895; DOI: https://doi.org/10.2967/jnmt.122.264895
Jaime Warren
MedAxiom, Neptune Beach, Florida
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    TABLE 1.

    99mTc-HMDP Cardiac Amyloidosis Protocol (1)

    ProtocolParameterRecommendation
    Prescan
     PreparationNo specific preparation; no fasting required
     ScanRest scanStandard
     Dose370–740 MBq (10–20 mCi) 99mTc-HMDP intravenouslyStandard
     Time from injection to acquisition2 or 3 hStandard
    General imaging parameters
     Field of viewHeart or chestStandard
    Whole-bodyOptional
     Image typePlanarStandard
    SPECT if planar is positiveRequired
     PositionSupineStandard
    UprightOptional
     Energy window140 keV, 15%–20%Standard
     CollimatorsLow-energy, high-resolutionStandard
     MatrixPlanar: 256 × 256 (minimum, 64 × 64)Standard
    SPECT: 128 × 128 (minimum, 64 × 64)Standard
     Pixel size3.5–6.5 mmStandard
    Planar parameters
     ViewsChest: anterior and lateralStandard
    Whole-body: from head to toeOptional
     Detector configuration90°Recommended
     Image duration (count-based)Planar: 750,000Standard
    Whole-body: 20 cm/minOptional
     Magnification1.46Standard
    SPECT parameters
     Angular range180°Standard
    360°Optional
     Detector configuration90°Standard
    180°Optional
     Electrocardiographic gatingOff; nongated imagingStandard
     Number of views/detector40/32Standard
     Time per stop20 s/25 sStandard
     Magnification1.46 (180° angular range) or 1.0 (360° angular range)Recommended
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Journal of Nuclear Medicine Technology: 53 (1)
Journal of Nuclear Medicine Technology
Vol. 53, Issue 1
March 1, 2025
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Alternative Isotope Options for Amyloidosis Imaging: A Technologist’s Perspective
Jaime Warren
Journal of Nuclear Medicine Technology May 2023, 264895; DOI: 10.2967/jnmt.122.264895
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  • Article
    • Abstract
    • WHY IS THERE A SHORTAGE? IS THERE AN ESTIMATE ON WHEN THIS TRACER WILL BE BACK?
    • IS THERE ANOTHER ISOTOPE OPTION?
    • WHY DOES 99MTC-HMDP WORK AS A SUBSTITUTE FOR 99MTC-PYROPHOSPHATE?
    • IS 99MTC-HMDP THE SAME THING AS 99MTC-MDP?
    • IS THERE A DIFFERENCE IN HOW THE PATIENT IS IMAGED USING 99MTC-HMDP VS. 99MTC-PYROPHOSPHATE?
    • IS IMAGE INTERPRETATION DIFFERENT WHEN 99MTC-HMDP IS USED?
    • WHAT ABOUT BILLING? ARE THERE DIFFERENCES WHEN 99MTC-HMDP IS USED?
    • DISCLOSURE
    • CONCLUSION
    • Footnotes
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More in this TOC Section

  • Patient Motion During Cardiac PET Imaging
  • Fitness for Purpose of Text-to-Image Generative Artificial Intelligence Image Creation in Medical Imaging
  • Logistics of Adopting 177Lu-Vipivotide Tetraxetan Therapy in a Community-Based Hospital Setting
Show more Brief Communication

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Keywords

  • cardiac amyloidosis
  • 99mTc-pyrophosphate
  • 99mTc-PYP
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Alternative Isotope Options for Amyloidosis Imaging: A Technologist’s Perspective
Jaime Warren
Journal of Nuclear Medicine Technology May 2023, 264895; DOI: 10.2967/jnmt.122.264895

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