TY - JOUR T1 - Alternative Isotope Options for Amyloidosis Imaging: A Technologist’s Perspective JF - Journal of Nuclear Medicine Technology JO - J. Nucl. Med. Technol. DO - 10.2967/jnmt.122.264895 SP - 264895 AU - Jaime Warren Y1 - 2023/05/16 UR - http://tech.snmjournals.org/content/early/2023/05/16/jnmt.122.264895.abstract N2 - The recent pyrophosphate shortages can limit the availability of 99mTc-pyrophosphate scans for cardiac amyloidosis. However, another radiotracer is available: 99mTc-hydroxymethylene diphosphonate (HMDP). 99mTc-HMDP, widely available in the United States for bone scanning, has effectively been used in Europe to diagnose transthyretin amyloidosis. 99mTc-HMDP and 99mTc-pyrophosphate have comparable blood clearance and sensitivity. The imaging protocols for 99mTc-HMDP and 99mTc-pyrophosphate are similar, except 99mTc-HMDP is imaged 2–3 h after injection and whole-body imaging is optional. The interpretation is also essentially the same; however, caution is needed because of the high soft-tissue uptake with 99mTc-HMDP, which can affect heart–to–contralateral-lung ratios. ER -