Article Figures & Data
Figures
- FIGURE 1.
Overview of timeline and PET/MRI protocol. GD-DO3A-butrol = gadobutrol; MOLLI = modified look-locker; MRAC = MRI-based attenuation correction.
- FIGURE 2.
18F-FDG PET SUVmean of myocardium of 15 patients at baseline and 1-mo follow-up. Uptake values for entire myocardium were categorized by regions supplied by LAD, left circumflex coronary artery, and right coronary artery. Mean value is indicated with +, and median is indicated as median bar. *Significant difference at 1-mo follow-up. LCX = left circumflex coronary artery; RC = right coronary artery; SUVbw = SUVmean based on body weight.
- FIGURE 3.
Mean cardiac functional parameters including LV end-diastolic volume, SV, and LVEF for 15 patients before and 1 mo after RT. Significant reduction at 1 mo after RT was shown in SV. Mean value is indicated with +, and median is indicated as median bar. *Significant difference at 1-mo follow-up. EDV = end-diastolic volume; EF = ejection fraction.
- FIGURE 4.
Mean ECVs before and 1 mo after RT. Significant increases in ECVs in apical and basal slices were observed at 1-mo follow-up. Mean value is indicated with +, and median is indicated as median bar. *Significant difference at 1-mo follow-up.
- FIGURE 5.
Presented are mean blood work measurements of hs-TnT, hs-CRP and erythrocyte sedimentation rate before and 1 mo after RT. Mean value is indicated with +, and median is indicated as median bar. ESR = erythrocyte sedimentation rate.
Tables
Parameter Data Mean age (y) 60 (range, 38–79) Staging (n) TCIS 3 T1 8 (1 recurrence) T2 3 T3 1 RT (n) Free-breathing RT 4 (27%) Tomotherapy 2 IMRT 1 VMAT 1 DIBH IMRT 11 (73%) Prescription dose (n) 42.5 Gy in 16 fractions 14 Boost of 10 Gy in 5 fractions 7 48 Gy in 16 fractions 1 Mean heart dose (Gy) 1.79 Mean LV dose (Gy) 2.07 Mean LAD dose (Gy) 2.78 Mean heart V5Gy 9.46% Mean maximum heart dose (Gy) 19.31 Mean maximum LAD dose (Gy) 8.41 Adjuvant chemotherapy (n) Yes 5 (33%) Herceptin 4 No 10 (67%) DIBH = deep inspiration breath-hold; IMRT = intensity-modulated radiation therapy; VMAT = volumetric-modulated arc therapy.
Parameter Baseline 1-mo follow-up Difference 18F-FDG PET SUVmean Left circumflex 1.52 1.62 6% LAD* 1.47 1.61 10% Right coronary 1.61 1.67 4% LV function EDV (mL) 123 115.92 −6% SV* (mL) 79.27 74 −7% EF (%) 65.4 64.25 −2% ECVs Apex* 0.289 0.307 6% Mid 0.271 0.275 3% Base* 0.268 0.279 5% Blood work hs-TnT (ng/L) 10 7.92 −21% hs-CRP (mg/L) 3.39 2.53 −25% Erythrocyte sedimentation rate (mm/h) 12.64 11.42 −10% ↵* Significant difference.
Parameter Mean dose Heart V5Gy Maximum dose Heart LV LAD Heart LAD 18F-FDG LAD r 0.12 0.04 −0.23 0.17 0.07 −0.24 P 0.74 0.91 0.53 0.63 0.85 0.51 SV r 0.25 0.32 0.22 0.21 0.14 0.37 P 0.46 0.34 0.52 0.53 0.69 0.27 ECV apex r 0.34 0.38 0.19 0.30 0.36 0.33 P 0.28 0.22 0.55 0.35 0.26 0.30 ECV base r 0.44 0.44 0.57 0.41 0.41 0.55 P 0.17 0.18 0.07 0.21 0.21 0.08
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