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Research ArticleTeaching Case Study

False-Positive 68Ga-DOTATATE PET/CT Findings in Hereditary Hypophosphatemia–Osteomalacia Mimicking Culprit Lesions of Tumor-Induced Osteomalacia

Rahul V. Parghane and Sandip Basu
Journal of Nuclear Medicine Technology March 2023, 51 (1) 73-74; DOI: https://doi.org/10.2967/jnmt.121.263776
Rahul V. Parghane
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, and Homi Bhabha National Institute, Mumbai, India
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Sandip Basu
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, and Homi Bhabha National Institute, Mumbai, India
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Abstract

68Ga-DOTATATE PET/CT is an important imaging modality for detection of culprit lesions of tumor-induced osteomalacia in clinically symptomatic patients with hypophosphatemia–osteomalacia. Somatostatin receptor expression may at times be observed in inflammatory or granulomatous conditions and in fractures or degenerative bone disease, leading to false-positive scan findings. We present a rare case of hereditary hypophosphatemia–osteomalacia that showed increased false-positive uptake (for possible tumor-induced osteomalacia lesions) in an inflammatory condition of the maxillary sinus and a fracture of the tibia on somatostatin receptor–based 68Ga-DOTATATE PET/CT.

  • 68Ga-DOTATATE PET/CT
  • hypophosphatemia–osteomalacia
  • tumor-induced osteomalacia
  • TIO
  • MRI

Footnotes

  • Published online Feb. 23, 2022.

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Journal of Nuclear Medicine Technology: 51 (1)
Journal of Nuclear Medicine Technology
Vol. 51, Issue 1
March 1, 2023
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False-Positive 68Ga-DOTATATE PET/CT Findings in Hereditary Hypophosphatemia–Osteomalacia Mimicking Culprit Lesions of Tumor-Induced Osteomalacia
Rahul V. Parghane, Sandip Basu
Journal of Nuclear Medicine Technology Mar 2023, 51 (1) 73-74; DOI: 10.2967/jnmt.121.263776

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False-Positive 68Ga-DOTATATE PET/CT Findings in Hereditary Hypophosphatemia–Osteomalacia Mimicking Culprit Lesions of Tumor-Induced Osteomalacia
Rahul V. Parghane, Sandip Basu
Journal of Nuclear Medicine Technology Mar 2023, 51 (1) 73-74; DOI: 10.2967/jnmt.121.263776
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Keywords

  • 68Ga-DOTATATE PET/CT
  • hypophosphatemia–osteomalacia
  • tumor-induced osteomalacia
  • TIO
  • MRI
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