False-Positive ⁶⁸Ga-DOTATATE PET/CT Findings in Hereditary Hypophosphatemia–Osteomalacia Mimicking Culprit Lesions of Tumor-Induced Osteomalacia

Abstract

⁶⁸Ga-DOTATATE PET/CT is an important imaging modality for detection of culprit lesions of tumor-induced osteomalacia in clinically symptomatic patients with hypophosphatemia–osteomalacia. Somatostatin receptor expression may at times be observed in inflammatory or granulomatous conditions and in fractures or degenerative bone disease, leading to false-positive scan findings. We present a rare case of hereditary hypophosphatemia–osteomalacia that showed increased false-positive uptake (for possible tumor-induced osteomalacia lesions) in an inflammatory condition of the maxillary sinus and a fracture of the tibia on somatostatin receptor–based ⁶⁸Ga-DOTATATE PET/CT.