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Research ArticleTeaching Case Study

Differential Tumor Biology Between Locoregional and Distant Metastasis in a TENIS Patient with Tyrosine Kinase Inhibitor–Resistant Recurrent Disease: Comparative Evaluation with 18F-FDG, 68Ga-DOTATATE, and 68Ga-PSMA-11 PET/CT

Sunita Nitin Sonavane and Sandip Basu
Journal of Nuclear Medicine Technology December 2022, 50 (4) 372-374; DOI: https://doi.org/10.2967/jnmt.121.263452
Sunita Nitin Sonavane
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Parel, India, and Homi Bhabha National Institute, Mumbai, India
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Sandip Basu
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Parel, India, and Homi Bhabha National Institute, Mumbai, India
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Abstract

We present the molecular PET/CT imaging profile of an interesting case of differentiated thyroid carcinoma that later transformed into TENIS (thyroglobulin elevation and negative iodine scintigraphy) with tyrosine kinase inhibitor–resistant recurrent, aggressive disease. The patient was evaluated to assess somatostatin receptor 2 or PSMA expression to explore whether there might be any effective targeted nuclear therapy. 18F-FDG, 68Ga-DOTATATE, and 68Ga-PSMA-11 PET/CT scans were obtained, all of which revealed tracer avidity in extensive locoregional disease. A large, ill-defined retropharyngeal and retrotracheal soft-tissue mass was seen to be eroding the cricoid cartilage and extending into the tracheal lumen and the left-sided strap muscles. In contrast, there was no definite uptake in the multiple lung nodules that were present bilaterally. The scan findings indicated a differential tumor biology between locoregional and distant metastasis.

  • thyroid carcinoma
  • TENIS
  • 18F-FDG
  • 68Ga-DOTATATE
  • 68Ga-PSMA-11
  • PET/CT

Footnotes

  • Published online Dec. 6, 2022.

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Journal of Nuclear Medicine Technology: 50 (4)
Journal of Nuclear Medicine Technology
Vol. 50, Issue 4
December 1, 2022
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Differential Tumor Biology Between Locoregional and Distant Metastasis in a TENIS Patient with Tyrosine Kinase Inhibitor–Resistant Recurrent Disease: Comparative Evaluation with 18F-FDG, 68Ga-DOTATATE, and 68Ga-PSMA-11 PET/CT
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Differential Tumor Biology Between Locoregional and Distant Metastasis in a TENIS Patient with Tyrosine Kinase Inhibitor–Resistant Recurrent Disease: Comparative Evaluation with 18F-FDG, 68Ga-DOTATATE, and 68Ga-PSMA-11 PET/CT
Sunita Nitin Sonavane, Sandip Basu
Journal of Nuclear Medicine Technology Dec 2022, 50 (4) 372-374; DOI: 10.2967/jnmt.121.263452

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Differential Tumor Biology Between Locoregional and Distant Metastasis in a TENIS Patient with Tyrosine Kinase Inhibitor–Resistant Recurrent Disease: Comparative Evaluation with 18F-FDG, 68Ga-DOTATATE, and 68Ga-PSMA-11 PET/CT
Sunita Nitin Sonavane, Sandip Basu
Journal of Nuclear Medicine Technology Dec 2022, 50 (4) 372-374; DOI: 10.2967/jnmt.121.263452
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Keywords

  • thyroid carcinoma
  • TENIS
  • 18F-FDG
  • 68Ga-DOTATATE
  • 68Ga-PSMA-11
  • PET/CT
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