Article Figures & Data
Figures
- FIGURE 1.
A 73-y-old woman (patient 2) with primary lung hemangioendothelioma. (A, B, and D) 68Ga-pentixafor PET/CT maximum-intensity projection (A) and cross-sectional PET/CT image (B) showing increased uptake (SUVmax, 13.0), with corresponding CT image (D). (C, E, and F) FACS analysis using CD184-PE showing stained CXCR4-positive tumor cells in scatterplots (C), photomicrograph with histopathologic disease evidence showing epithelioid tumor cells (hematoxylin and eosin, ×40) (E) and immunohistochemistry staining with CD31 showing diffuse membranous positivity (F).
- FIGURE 2.
A 70-y-old woman (patient 4) with secondary lung cancer disease. (A) 68Ga-pentixafor PET/CT maximum-intensity projection showing increased uptake in lung and in multiple sarcomatoid lesions. (B, D, and F) Cross-sectional PET/CT image showing increased (SUVmax, 9.5) uptake in metastatic lung lesion (B), in posterior subcutaneous lesions and left lateral aspect of scalp (SUVmax, 4.6) (D), and in lytic expansile lesion with soft-tissue component involving lateral aspect of fifth rib (SUVmax, 5.4) (F). (C) FACS analysis using CD184-PE showing stained CXCR4-positive tumor cells in scatterplots. (E) Photomicrograph with histopathologic disease evidence (hematoxylin and eosin, ×40).
Tables
FACS analysis Patient no. Age (y) Sex Histopathology 68Ga-pentixafor PET SUVmax MFI CXCR-positive tumor cells (%) 1 73 F Sarcomatoid carcinoma (primary tumor) 6.34 110.50 2.70 2 33 F Hemangioendothelioma (primary tumor) 13.0 682.0 73.60 3 68 M Hemangiopericytoma (primary tumor) 3.0 27.90 2.50 4 70 F Lung metastasis (primary sarcoma) 9.5 191.20 45.2 5 40 M Lung metastasis (primary renal cell carcinoma) 6.0 62.0 47.0 6 58 M Lung metastasis (unknown primary) 7.5 216.6 59.2
