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Research ArticleRadionuclide Therapy

Analysis of Residence Time, Effective Half-Life, and Internal Dosimetry Before Radioiodine Therapy

Caio Vinicius Oliveira, Tatiane Sabriela Cagol Camozzato, Patricia Fernanda Dorow and Jéssica Pasqueta
Journal of Nuclear Medicine Technology September 2022, 50 (3) 233-239; DOI: https://doi.org/10.2967/jnmt.121.263502
Caio Vinicius Oliveira
Federal Institute of Education, Science, and Technology of Santa Catarina, Florianópolis, Santa Catarina, Brazil
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Tatiane Sabriela Cagol Camozzato
Federal Institute of Education, Science, and Technology of Santa Catarina, Florianópolis, Santa Catarina, Brazil
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Patricia Fernanda Dorow
Federal Institute of Education, Science, and Technology of Santa Catarina, Florianópolis, Santa Catarina, Brazil
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Jéssica Pasqueta
Federal Institute of Education, Science, and Technology of Santa Catarina, Florianópolis, Santa Catarina, Brazil
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  • FIGURE 1.
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    FIGURE 1.

    Measurement of regions of interest of set of anterior and posterior conjugate images and their respective images for scattered radiation correction.

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    FIGURE 2.

    Time–activity fitted curves for assessed patients. P1–P5 = patients 1–5.

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    FIGURE 3.

    Comparison of absorbed dose by activity calculated by OLINDA/EXM and EANM.

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    FIGURE 4.

    Recovery coefficient of definitive experiment. ● = apparent volume; × = true sphere volume.

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    FIGURE 5.

    (A) From left to right: axial, sagittal, and coronal SPECT/CT reconstruction of remaining thyroid tissue (arrows). (B) Activity concentration function in organ target.

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    FIGURE 6.

    (A) Scattering-point function of SPECT of a cylinder of 22 mL filled with 131I. (B) Comparison of apparent and actual volume. kcnt = kilocount.

Tables

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    TABLE 1.

    Variables for Internal Dosimetry Cases

    Patient no.SexAge (y)Height (cm)Weight (kg)Body mass indexBlood volume (mL)Residence time per mL of blood (h)
    BodyBlood
    1F501615922.83,532.822.10.00088
    2M711827622.95,402.639.40.00102
    3M361879527.26,061.812.60.00029
    4M281788225.95,432.819.30.00050
    5F291655720.93,732.222.00.00083
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    TABLE 2.

    Maximum Activity for Assessed Case Group

    Patient no.Dose in blood per administered activity (mGy/MBq)Maximum activity (GBq)
    Limit, 2 GyLimit, 1.3 Gy
    10.12216.3910.66
    20.15213.208.58
    30.04346.7230.37
    40.07327.4217.82
    50.11717.0911.11
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    TABLE 3.

    Effective and Biologic Times for Half and Quarter of Initial Activity of 131I

    Patient no.Effective (h)Biologic (h)
    HalfQuarterHalfQuarter
    116.128.917.631.3
    228.253.13361.6
    37.613.17.913.6
    412.523.213.324.7
    515.629.516.932
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Journal of Nuclear Medicine Technology: 50 (3)
Journal of Nuclear Medicine Technology
Vol. 50, Issue 3
September 1, 2022
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Analysis of Residence Time, Effective Half-Life, and Internal Dosimetry Before Radioiodine Therapy
Caio Vinicius Oliveira, Tatiane Sabriela Cagol Camozzato, Patricia Fernanda Dorow, Jéssica Pasqueta
Journal of Nuclear Medicine Technology Sep 2022, 50 (3) 233-239; DOI: 10.2967/jnmt.121.263502

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Analysis of Residence Time, Effective Half-Life, and Internal Dosimetry Before Radioiodine Therapy
Caio Vinicius Oliveira, Tatiane Sabriela Cagol Camozzato, Patricia Fernanda Dorow, Jéssica Pasqueta
Journal of Nuclear Medicine Technology Sep 2022, 50 (3) 233-239; DOI: 10.2967/jnmt.121.263502
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Keywords

  • nuclear medicine
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  • thyroid gland neoplasms
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