Radioiodine Therapy in Patient with Differentiated Thyroid Cancer and End-Stage Renal Disease on Maintenance Hemodialysis: Case Report with Review of Literature

Article Figures & Data

TABLE 1.

Summary of Literature on Hemodialysis in Patients with CKD After Radioiodine Therapy (n = 23)

Study	Age (y)	Cancer	Dose (mCi)*	Time of dialysis	Conclusion of studies
Vermandel (10)	67	PTC	60	42, 90 h	Use 30% reduction in dose for ablative and adjuvant treatments; for metastatic disease, dosimetry should be done; first dialysis 42 h after dose
	47	PTC	77, 82
	63	PTC	61
	63	PTC	50
	29	PTC	60
	71	VC	101
Daumerie (11)	42	PTC	25 in 2 sessions 6 mo apart	2, 5, 7 d	Administer 25% of prescribed activity; first dialysis 24 h after dose
	62	PTC
	27	PTC
Jiménez (16)	42	PTC	75	Daily for 5 d	Use dosimetry to determine dose; dialysis every day for 5 d
	51	PTC	87
	34	PTC	120
Holst (9)	40	PTC	98	2, 3, 4 d	Use 21%–28% of dose; dialysis at days 2 and 4
Mello (12)	42	PTC	100	41, 98 h	Use dosimetry to determine dose
Sinsakul (17)	43	PTC	100	20 or 24 h	Perform dialysis 2–24 h after dose
	56	PTC	157
Culpepper (14)	56	FTC	129	24, 43, 66 h	None
Howard (8)	34	PTC	80	—	Administer 22% of empiric dose; dialysis 48 h after dose
Morrish (13)	36	PTC	50, 120, 150, 250 over 4 y	24–48 h	Use significantly larger ¹³¹I dose; first dialysis 48 h after dose
Magne (21)	43	PTC	50	1, 3, 6 d	Increase dose up to 25%
Gallegos-Villalobos (22)	51	PTC	100	1, 2 d; administer same dose with normal renal function	Administer same dose with normal renal function; use 2 subsequent dialysis sessions daily
	52	PTC	100
Bhat (23)	49	PTC	50	15, 27, 43 h	None