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Research ArticleBrief Communication

Amino Acid PET Imaging with 18F-DOPA in the Evaluation of Pediatric Brain Tumors

Mehdi Djekidel, Rahaf AlSadi, Othmane Bouhali and Ata Ur Rehman Maaz
Journal of Nuclear Medicine Technology June 2022, 50 (2) 137-142; DOI: https://doi.org/10.2967/jnmt.121.263050
Mehdi Djekidel
1Division of Nuclear Medicine and Molecular Imaging, Department of Diagnostic Imaging, Sidra Medicine, Doha, Qatar;
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Rahaf AlSadi
2Department of Science, Texas A&M University at Qatar, Doha, Qatar;
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Othmane Bouhali
2Department of Science, Texas A&M University at Qatar, Doha, Qatar;
3Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha, Qatar; and
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Ata Ur Rehman Maaz
4Division of Hematology and Oncology, Department of Pediatrics, Sidra Medicine, Doha, Qatar
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Abstract

Although MRI is the workhorse of initial evaluation and follow-up in brain tumors, there are growing data recommending incorporation of amino acid PET imaging at different stages in the management of these patients. Recent recommendations on nuclear medicine and neurooncology clinical practice support the use of amino acid imaging for brain tumors. Methods: We present 4 pediatric brain tumor cases imaged with 3,4-dihydroxy-6-18F-fluoro-l-phenylalanine (18F-DOPA), and we review the literature. Results: 18F-DOPA showed low level/no uptake in benign conditions and in inflammatory postoperative changes. It showed better definition of viable tumor boundaries than MRI. Conclusion: Considering that 18F-DOPA is Food and Drug Administration–approved for the evaluation of parkinsonian syndromes, this tracer could be used clinically for other valuable clinical indications, such as brain tumor evaluations. The value of this use seems to be well established in adults, and evidence of its value in pediatrics has been growing as well.

  • brain tumors
  • amino acid imaging
  • PET
  • nuclear medicine

Footnotes

  • Published online Apr. 19, 2022.

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Journal of Nuclear Medicine Technology: 50 (2)
Journal of Nuclear Medicine Technology
Vol. 50, Issue 2
June 1, 2022
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Amino Acid PET Imaging with 18F-DOPA in the Evaluation of Pediatric Brain Tumors
Mehdi Djekidel, Rahaf AlSadi, Othmane Bouhali, Ata Ur Rehman Maaz
Journal of Nuclear Medicine Technology Jun 2022, 50 (2) 137-142; DOI: 10.2967/jnmt.121.263050

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Amino Acid PET Imaging with 18F-DOPA in the Evaluation of Pediatric Brain Tumors
Mehdi Djekidel, Rahaf AlSadi, Othmane Bouhali, Ata Ur Rehman Maaz
Journal of Nuclear Medicine Technology Jun 2022, 50 (2) 137-142; DOI: 10.2967/jnmt.121.263050
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Keywords

  • brain tumors
  • amino acid imaging
  • PET
  • nuclear medicine
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