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Research ArticleImaging

Whole-Skeleton SUVmean Measured on 18F-NaF PET/CT Studies as a Prognostic Indicator in Patients with Breast Cancer Metastatic to Bone

José Flávio Gomes Marin, Paulo Schiavom Duarte, Monique Beraldo Ordones, Heitor Naoki Sado, Marcelo Tatit Sapienza and Carlos Alberto Buchpiguel
Journal of Nuclear Medicine Technology June 2022, 50 (2) 119-125; DOI: https://doi.org/10.2967/jnmt.121.262907
José Flávio Gomes Marin
1Division of Nuclear Medicine, São Paulo Cancer Institute, São Paulo, Brazil; and
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Paulo Schiavom Duarte
1Division of Nuclear Medicine, São Paulo Cancer Institute, São Paulo, Brazil; and
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Monique Beraldo Ordones
1Division of Nuclear Medicine, São Paulo Cancer Institute, São Paulo, Brazil; and
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Heitor Naoki Sado
1Division of Nuclear Medicine, São Paulo Cancer Institute, São Paulo, Brazil; and
2Division of Nuclear Medicine, Department of Radiology and Oncology, Medical School of University of São Paulo, São Paulo, Brazil
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Marcelo Tatit Sapienza
2Division of Nuclear Medicine, Department of Radiology and Oncology, Medical School of University of São Paulo, São Paulo, Brazil
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Carlos Alberto Buchpiguel
1Division of Nuclear Medicine, São Paulo Cancer Institute, São Paulo, Brazil; and
2Division of Nuclear Medicine, Department of Radiology and Oncology, Medical School of University of São Paulo, São Paulo, Brazil
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Abstract

In this work, we assessed the association between the whole-skeleton SUVmean measured on 18F-NaF PET/CT studies and overall survival (OS) in patients with breast cancer metastatic to bone. Methods: We retrospectively analyzed 176 patients with breast cancer and metastatic bone disease who underwent 18F-NaF PET/CT. The outcomes of the patients (dead or alive) were based on the last information available in their files. The SUVmean and SUVmax were measured in a whole-skeleton volume of interest (wsVOI). The wsVOI was based on the CT component of the PET/CT study using Hounsfield unit thresholds. The wsVOI was then applied to the 18F-NaF PET image. Univariate analyses were performed to assess the association of SUVs with OS. We also analyzed the association between OS and patient age; presence of visceral metastatic disease; histologic subtype; presence of hormone receptors; human epidermal growth factor receptor 2 expression; and creatinine, cancer antigen (CA) 15-3, and alkaline phosphatase levels. The variables statistically significant in the univariate analyses were included in a multivariate Cox regression OS analysis. Results: In the univariate analyses, there were associations between OS and whole-skeleton SUVmean and SUVmax, estrogen receptor status, and CA15-3 and alkaline phosphatase levels. In the multivariate analysis, all variables that were statistically significant in the univariate analyses were associated with OS, with the exception of CA15-3. Conclusion: In patients with breast cancer metastatic to bone, whole-skeleton SUVmean is an independent predictor of OS.

  • 18F
  • PET/CT
  • 18F-NaF
  • breast cancer
  • bone metastases

Footnotes

  • Published online Nov. 8, 2021.

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Journal of Nuclear Medicine Technology: 50 (2)
Journal of Nuclear Medicine Technology
Vol. 50, Issue 2
June 1, 2022
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Whole-Skeleton SUVmean Measured on 18F-NaF PET/CT Studies as a Prognostic Indicator in Patients with Breast Cancer Metastatic to Bone
José Flávio Gomes Marin, Paulo Schiavom Duarte, Monique Beraldo Ordones, Heitor Naoki Sado, Marcelo Tatit Sapienza, Carlos Alberto Buchpiguel
Journal of Nuclear Medicine Technology Jun 2022, 50 (2) 119-125; DOI: 10.2967/jnmt.121.262907

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Whole-Skeleton SUVmean Measured on 18F-NaF PET/CT Studies as a Prognostic Indicator in Patients with Breast Cancer Metastatic to Bone
José Flávio Gomes Marin, Paulo Schiavom Duarte, Monique Beraldo Ordones, Heitor Naoki Sado, Marcelo Tatit Sapienza, Carlos Alberto Buchpiguel
Journal of Nuclear Medicine Technology Jun 2022, 50 (2) 119-125; DOI: 10.2967/jnmt.121.262907
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Keywords

  • 18F
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  • 18F-NaF
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