RT Journal Article
SR Electronic
T1 Whole-Skeleton SUV<sub>mean</sub> Measured on <sup>18</sup>F-NaF PET/CT Studies as a Prognostic Indicator in Patients with Breast Cancer Metastatic to Bone
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 119
OP 125
DO 10.2967/jnmt.121.262907
VO 50
IS 2
A1 Gomes Marin, José Flávio
A1 Duarte, Paulo Schiavom
A1 Ordones, Monique Beraldo
A1 Sado, Heitor Naoki
A1 Sapienza, Marcelo Tatit
A1 Buchpiguel, Carlos Alberto
YR 2022
UL http://tech.snmjournals.org/content/50/2/119.abstract
AB In this work, we assessed the association between the whole-skeleton SUVmean measured on 18F-NaF PET/CT studies and overall survival (OS) in patients with breast cancer metastatic to bone. Methods: We retrospectively analyzed 176 patients with breast cancer and metastatic bone disease who underwent 18F-NaF PET/CT. The outcomes of the patients (dead or alive) were based on the last information available in their files. The SUVmean and SUVmax were measured in a whole-skeleton volume of interest (wsVOI). The wsVOI was based on the CT component of the PET/CT study using Hounsfield unit thresholds. The wsVOI was then applied to the 18F-NaF PET image. Univariate analyses were performed to assess the association of SUVs with OS. We also analyzed the association between OS and patient age; presence of visceral metastatic disease; histologic subtype; presence of hormone receptors; human epidermal growth factor receptor 2 expression; and creatinine, cancer antigen (CA) 15-3, and alkaline phosphatase levels. The variables statistically significant in the univariate analyses were included in a multivariate Cox regression OS analysis. Results: In the univariate analyses, there were associations between OS and whole-skeleton SUVmean and SUVmax, estrogen receptor status, and CA15-3 and alkaline phosphatase levels. In the multivariate analysis, all variables that were statistically significant in the univariate analyses were associated with OS, with the exception of CA15-3. Conclusion: In patients with breast cancer metastatic to bone, whole-skeleton SUVmean is an independent predictor of OS.