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Research ArticleTeaching Case Studies

Imaging Biomarkers in Lung Cancer with 68Ga-DOTATATE, 18F-Fluoride, and 18F-FDG PET/CT Scans and the Theranostics Paradigm

Mehdi Djekidel, Ghulam Syed and Aladdin Kanbour
Journal of Nuclear Medicine Technology September 2021, 49 (3) 281-283; DOI: https://doi.org/10.2967/jnmt.120.258343
Mehdi Djekidel
1NCCCR, Division of Oncology, Hamad Medical Corporation, Doha, Qatar;
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Ghulam Syed
2Department of Radiology, Division of Nuclear Medicine, Hamad Medical Corporation, Doha, Qatar; and
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Aladdin Kanbour
3Department of Radiology, Division of Nuclear Medicine, Sidra Medicine, Doha, Qatar
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  • FIGURE 1.
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    FIGURE 1.

    18F-FDG PET/CT scan. Initial staging showing intensely 18F-FDG–avid right-upper-lobe mass with additional 18F-FDG–avid mediastinal lymph nodes. From right to left maximum-intensity-projection PET, coronal PET, coronal PET/CT, and axial PET/CT images.

  • FIGURE 2.
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    FIGURE 2.

    18F-fluoride PET/CT scan. Diffuse bony metastasis with intense 18F-fluoride uptake is seen. From right to left maximum-intensity-projection PET, coronal PET, sagittal PET/CT, and coronal PET/CT images.

  • FIGURE 3.
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    FIGURE 3.

    68Ga-DOTATATE PET/CT scan. Diffuse bony metastasis is noted; uptake of 68Ga-DOTATATE is less prominent than that of 18F-fluoride in Figure 2. Liver and pleural involvement seen on subsequent 18F-FDG scan 1 wk later is not clearly appreciated with 68Ga-DOTATATE. From right to left maximum-intensity-projection PET, coronal PET, sagittal PET/CT, and coronal PET/CT images.

  • FIGURE 4.
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    FIGURE 4.

    18F-FDG PET scan showing diffuse bony lesions but also detecting pleural and very minimal subtle liver disease not visualized on 68Ga-DOTATATE scan. From right to left maximum-intensity-projection PET, coronal PET, coronal PET/CT, and sagittal PET/CT images.

  • FIGURE 5.
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    FIGURE 5.

    (A) Initial staging 18F-FDG PET/CT scan. (B) Seven months later, 18F-fluoride PET/CT scan shows diffuse bony metastasis. (C) Additional 68Ga-DOTATATE PET/CT scan 2 wk later shows bony lesions less prominently than on 18F-fluoride scan, somewhat similar to follow-up 18F-FDG PET/CT scan. (D) Follow-up 18F-FDG PET/CT scan 1 wk later shows bony lesions and pleural and liver disease.

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Journal of Nuclear Medicine Technology: 49 (3)
Journal of Nuclear Medicine Technology
Vol. 49, Issue 3
September 1, 2021
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Imaging Biomarkers in Lung Cancer with 68Ga-DOTATATE, 18F-Fluoride, and 18F-FDG PET/CT Scans and the Theranostics Paradigm
Mehdi Djekidel, Ghulam Syed, Aladdin Kanbour
Journal of Nuclear Medicine Technology Sep 2021, 49 (3) 281-283; DOI: 10.2967/jnmt.120.258343
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Keywords

  • lung cancer
  • lung adenocarcinoma
  • 18F-FDG
  • 68Ga-DOTATATE
  • 18F-fluoride
  • theranostics
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Imaging Biomarkers in Lung Cancer with 68Ga-DOTATATE, 18F-Fluoride, and 18F-FDG PET/CT Scans and the Theranostics Paradigm
Mehdi Djekidel, Ghulam Syed, Aladdin Kanbour
Journal of Nuclear Medicine Technology Sep 2021, 49 (3) 281-283; DOI: 10.2967/jnmt.120.258343

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