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Research ArticleImaging

Pilot Study: Texture Analysis of PET Imaging Demonstrates Changes in 18F-FDG Uptake of the Brain After Prophylactic Cranial Irradiation

David M. Sawyer, Travis W. Sawyer, Naghmehossadat Eshghi, Charles Hsu, Russell J. Hamilton, Linda L. Garland and Phillip H. Kuo
Journal of Nuclear Medicine Technology March 2021, 49 (1) 34-38; DOI: https://doi.org/10.2967/jnmt.120.248393
David M. Sawyer
1Department of Medical Imaging, University of Arizona, Tucson, Arizona
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Travis W. Sawyer
2College of Optical Sciences, University of Arizona, Tucson, Arizona
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Naghmehossadat Eshghi
1Department of Medical Imaging, University of Arizona, Tucson, Arizona
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Charles Hsu
3Department of Radiation Oncology, University of Arizona, Tucson, Arizona
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Russell J. Hamilton
3Department of Radiation Oncology, University of Arizona, Tucson, Arizona
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Linda L. Garland
4Department of Medicine, University of Arizona; University of Arizona Cancer Center, Tucson, Arizona; and
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Phillip H. Kuo
1Department of Medical Imaging, University of Arizona, Tucson, Arizona
4Department of Medicine, University of Arizona; University of Arizona Cancer Center, Tucson, Arizona; and
5Department of Biomedical Engineering, University of Arizona, Tucson, Arizona
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Abstract

Prophylactic cranial irradiation (PCI) is used to decrease the probability of developing brain metastases in patients with small cell lung cancer and has been linked to deleterious cognitive effects. Although no well-established imaging markers for these effects exist, previous studies have shown that structural and metabolic changes in the brain can be detected with MRI and PET. This study used an image processing technique called texture analysis to explore whether global changes in brain glucose metabolism could be characterized in PET images. Methods: 18F-FDG PET images of the brain from patients with small cell lung cancer, obtained before and after the administration of PCI, were processed using texture analysis. Texture features were compared between the pre- and post-PCI images. Results: Multiple texture features demonstrated statistically significant differences before and after PCI when texture analysis was applied to the brain parenchyma as a whole. Regional differences were also seen but were not statistically significant. Conclusion: Global changes in brain glucose metabolism occur after PCI and are detectable using advanced image processing techniques. These changes may reflect radiation-induced damage and thus may provide a novel method for studying radiation-induced cognitive impairment.

  • texture analysis
  • PET
  • prophylactic cranial irradiation

Footnotes

  • Published online Oct. 5, 2020.

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Journal of Nuclear Medicine Technology: 49 (1)
Journal of Nuclear Medicine Technology
Vol. 49, Issue 1
March 1, 2021
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Pilot Study: Texture Analysis of PET Imaging Demonstrates Changes in 18F-FDG Uptake of the Brain After Prophylactic Cranial Irradiation
David M. Sawyer, Travis W. Sawyer, Naghmehossadat Eshghi, Charles Hsu, Russell J. Hamilton, Linda L. Garland, Phillip H. Kuo
Journal of Nuclear Medicine Technology Mar 2021, 49 (1) 34-38; DOI: 10.2967/jnmt.120.248393

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Pilot Study: Texture Analysis of PET Imaging Demonstrates Changes in 18F-FDG Uptake of the Brain After Prophylactic Cranial Irradiation
David M. Sawyer, Travis W. Sawyer, Naghmehossadat Eshghi, Charles Hsu, Russell J. Hamilton, Linda L. Garland, Phillip H. Kuo
Journal of Nuclear Medicine Technology Mar 2021, 49 (1) 34-38; DOI: 10.2967/jnmt.120.248393
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Keywords

  • texture analysis
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